Protein Alignment Cyp6a9 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 127/516 - (24%)
• Similarity: 216/516 - (41%)
• Gaps: 86/516 - (16%)

  Fly     6 VLLAIVVVLV-GYLLLKWRRALHYWQNLDIPCEEPHILMGSL-----TGVQTSRSFSAIWMDYYN 64
            :||...|:|. |.......||...::::..| ..|..|:|.|     ......|....:::|:..
  Rat     6 LLLGSAVLLAFGLCCTFVHRARSRYEHIPGP-PRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAK 69

  Fly    65 KFRGTGPFAGFYWFQRPGILVLD-ISLAKLILIKEFNKFTDRGFYHNTE---DDPLSGQLFL--L 123
            |:   ||......|.:..::|.. .|:.|.::..::||  |...|...:   .:.|.||..:  .
  Rat    70 KY---GPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNK--DSKMYRAIQTVFGERLFGQGLVSEC 129

  Fly   124 DGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGT 188
            |..:|...|..:...|:...:..:..|..:...:.:|:.....:....|.::|:|...|.|::..
  Rat   130 DYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAK 194

  Fly   189 CAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIV 253
            .|||:|.|.|         :|.:.       |:..|.....:.::...:........:...||.:
  Rat   195 AAFGMETSML---------LGAQK-------PLSQAVKVMLEGISASRNTLAKFMPGKRKQLREI 243

  Fly   254 RETVAF----------REKNNIRRN-----DFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAF 303
            ||::..          |.:..::|.     |.:.|::        |:|.|..    .:|:....|
  Rat   244 RESIRLLRQVGKDWVQRRREALKRGEDVPADILTQIL--------KAEEGAQ----DDEVLLDNF 296

  Fly   304 V-FFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISET 367
            | ||.||.|||:..:.|.:.||::..:|..|::.|..||:|. ...:.||.:..:.||.||:.|:
  Rat   297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGS-KRHLDYEDLGRLQYLSQVLKES 360

  Fly   368 LRLYT----VLPVLNRECLED-YEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFS 427
            ||||.    ...:|..|.|.| ..|||:        .|:|.....|.|.:..:.:|.|||||.|.
  Rat   361 LRLYPPAWGTFRLLEEETLIDGVRVPGN--------TPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417

  Fly   428 PERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRF--------KFSVCEQTTI 480
            |...|.|  ..:.||..|.|:|||.:|.||:.:..:|.|:.|.        :|.:.||.|:
  Rat   418 PGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	112/448 (25%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	114/460 (25%)