DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	211/502 - (42%)
Similarity:	319/502 - (63%)	Gaps:	24/502 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAIVVVLVGYLL---LKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGT 69
            |.::|..||.||   |:|..:  ||....:..|.|....|:::|:.....::.|.:..|.||||.
  Fly     4 LLVLVFTVGLLLYVKLRWHYS--YWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGV 66

  Fly    70 GPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSK 134
            ..:.|::.|....:.::|:.|.:.|:|::|:.|.|||.:||..||||:|.|..|||.:|:.:|..
  Fly    67 ERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQN 131

  Fly   135 LSYTFTSGKMKYMFPTVVKVGHEFIEV----FGQAMEKSPIVEVRDILARFTTDVIGTCAFGIEC 195
            |:..|||||||:|||.:|:||.:..:.    .|:       :|.:|:.|||||||||:||||:||
  Fly   132 LTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE-------IEAKDLCARFTTDVIGSCAFGLEC 189

  Fly   196 SSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIVRETVAFR 260
            :||:|||::||.|||....|..|..:..||:.:...|||:|..::...|...|||..||:|:.:|
  Fly   190 NSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLDYR 254

  Fly   261 EKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELA 325
            .:.||.|||.:..|::|       .|.|....|:.|::||||.|||.|||:||||||.|.|||||
  Fly   255 RRENIHRNDLIQLLMEL-------GEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELA 312

  Fly   326 QHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGH 390
            .:.|:|:|:|.|...|:.:.|.::||:|:::|.|||||::||||.|.:||.|.|...::|::| :
  Fly   313 LNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIP-N 376

  Fly   391 PKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFG 455
            ...:::.|..::||..::|.|.:||.:|..|:|..|.||.:|.|....:||||:|||||||.|||
  Fly   377 SNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFG 441

  Fly   456 QMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            ::|.:.||..|:..||||..|:|.||:.:|.:.||||::.|:.|::|
  Fly   442 KLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	199/467 (43%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	194/457 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471820
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800