DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	227/506 - (44%)
Similarity:	335/506 - (66%)	Gaps:	10/506 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPF 72
            :|:|.|::|.......:...||:...:|.|.|..::|::.|:.....|..|....|.||:|.||.
  Fly     5 IALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGPI 69

  Fly    73 AGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSKLSY 137
            ||.|.|.:...|:.|:...|.::||:|:.|.|||.:.|..||||:|.||.|:|::|::||.||:.
  Fly    70 AGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLTP 134

  Fly   138 TFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPI----VEVRDILARFTTDVIGTCAFGIECSSL 198
            .|||||:|.|...:|.||....:...:|::::.:    ||::|:.|||||||||:||||:||:||
  Fly   135 VFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSL 199

  Fly   199 KDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIVRETVAFREKN 263
            :||.||||..||.....:||..:..:||.:...|||:|.:|:..::...||:..|:.||.:|.||
  Fly   200 QDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVKNTVDYRLKN 264

  Fly   264 NIRRNDFMDQLIDLKNSPLTKSESGESVN----LTIEEMAAQAFVFFGAGFETSSTTMGFALYEL 324
            .|:||||::|:|:|:......::.|:.::    ||:|:|||||||||.|||||||:||...||||
  Fly   265 GIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYEL 329

  Fly   325 AQHQDIQDRVRKECQEVIGKYN-GEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVP 388
            |...|||.|:|:|.:.|:...: ||:.|:.:..|.|||||:|||||.:.:||.|.||..:||::|
  Fly   330 ALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIP 394

  Fly   389 GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMR 453
             :...|:.||:..|||...:|.|.::|..|..|:|..|.||.||.|..:.:||||||||||||:|
  Fly   395 -NSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLR 458

  Fly   454 FGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVERV 504
            ||::||:.||..|:.||||||..:|.:|:::|||:||:::..||:||||||
  Fly   459 FGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVERV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	215/472 (46%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	216/474 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970