DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	161/523 - (30%)
Similarity:	274/523 - (52%)	Gaps:	52/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRR-ALHYWQNLDIPCEEPHILMGSLTGVQTSR-SFSAIWMDYYNKFRG 68
            |.:.:|:..:|.||.||.. ....::..::..|:|:..:|::......: ||.....::||:.|
  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTR- 67

  Fly    69 TGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDP----LSGQLFLLDGQKWK 129
            .....|.:..:.|.|.:.|..|.|.|.:|:|:.|.:    |.|.:.|    ::..|.::..|.|:
  Fly    68 HHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPN----HQTLNIPNERLVNDMLNVMRDQHWR 128

  Fly   130 SMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAME----KSPI--------VEVRDILARFT 182
            :|||.|:..|||.||:.|| |::.      |.|.|.:|    ..||        ::::.:..:.:
  Fly   129 NMRSVLTPVFTSAKMRNMF-TLMN------ESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLS 186

  Fly   183 TDVIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQ-NLARRL--HMKITLEE 244
            .|||.|.|||::.:|..|||.||..:|:...|.:     |:.|:.... .||.::  ..|:|:.:
  Fly   187 NDVIATTAFGLKVNSFDDPENEFHTIGKTLAFSR-----GLPFLKFMMCLLAPKVFNFFKLTIFD 246

  Fly   245 AEH--FFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFG 307
            :.:  :|:|:|.:.:.:|||:||.|.|.:..|::      .|.||.:  |.|.:|:.||.|:||.
  Fly   247 STNVEYFVRLVVDAMQYREKHNITRPDMIQLLME------AKKESKD--NWTDDEIVAQCFIFFF 303

  Fly   308 AGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNG-EITYESMKDMVYLDQVISETLRLY 371
            |.||.:|..:....|||.::.|||:|:.:|.:|......| .:||::.::|.|:|.||||:||.:
  Fly   304 AAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKW 368

  Fly   372 TVLPVLNRECLEDYEV---PGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKE 433
            |:....:|.|.:||.:   .|...:..|.|..:.||...:|.||:.:..|..|:|:.||..|.|:
  Fly   369 TLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKD 433

  Fly   434 RDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIF 498
            .....:||||.|||:|||.|:..|||:..|..|:..:|.....:||..:..|.:.|.|...||.:
  Fly   434 LIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFW 498

  Fly   499 LKV 501
            :::
  Fly   499 MQL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	154/489 (31%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	146/465 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461268
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800