DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	139/523 - (26%)
Similarity:	254/523 - (48%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVG--YLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSR-----SFSAIWMDYY 63
            :.|.:|.::||  |.:|.|.  ..||:...:|..:|.:|.|:...:.|.:     ....|:..|.
  Fly     4 ITLTLVSLVVGLLYAVLVWN--YDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYK 66

  Fly    64 NKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTE---DDPLSGQLFLLDG 125
            ||:...|.|..    :.|.:||::.:||:.:.:..|..|.|.....|.:   |...:...|.|.|
  Fly    67 NKYDAVGIFGS----RSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTG 127

  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAME--KSPIVEVRDILARFTTDVIGT 188
            :|||:.|:.::...|.|::|.::|...||..:..|...:.:.  ....::.:.:...|||:::..
  Fly   128 EKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTD 192

  Fly   189 CAFGIECSSLKDPEAEFRVMGR-RAIFEQRHGPIGIAFI--NSFQNLARRLHMKITLEEAEHFFL 250
            |..|:...|..|....  :|.: ..:|.|....: :.||  :||.:|:..:.::....:.|.||:
  Fly   193 CVLGLGAESFSDKPTP--IMSKINDLFNQPWTFV-LFFILTSSFPSLSHLIKLRFVPVDVERFFV 254

  Fly   251 RIVRETVAFREK-----NNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGF 310
            .::...|..|..     ....|:||:|.::.|          ||..||...::.|.:..|...||
  Fly   255 DLMGSAVETRRAQLAAGKQFERSDFLDYILQL----------GEKRNLDNRQLLAYSMTFLLDGF 309

  Fly   311 ETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLP 375
            ||::|.:...|..|.::::.|:.:|:|.:..:  .:|.|.:|.:.|:.|||..:.||:||:....
  Fly   310 ETTATVLAHILLNLGRNKEAQNLLREEIRSHL--QDGTIAFEKLSDLPYLDACVQETIRLFPPGF 372

  Fly   376 VLNRECLEDYEVPGH--PKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNF-SPERVKE-RDS 436
            :.|:.|.|..|:|..  |.:|::||..|::|......||:.:.||.:|.|:.| .|:..|. |:.
  Fly   373 MSNKLCTESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFRER 437

  Fly   437 VEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            ..::.||||||.||||||..:|.::.:..||::|...:.::|.....|.....:.....||:|.:
  Fly   438 GVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLRGGIWLDL 502

  Fly   502 ERV 504
            |::
  Fly   503 EKL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	128/485 (26%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	128/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460968
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900