DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	128/512 - (25%)
Similarity:	240/512 - (46%)	Gaps:	35/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMD-YYNKFRGTG 70
            ::|.::.|: |:.|.|.  ..||:...||..:....:||...|.|.:......:| .|.:::.|.
  Fly    10 VIAAILALI-YVFLTWN--FSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTD 71

  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGF--YHNTEDDP-LSGQLFLLDGQKWKSMR 132
            ...|.:..:.|.::|.....|..|.:.:|..|.|...  :.:::.|| |:...|:|.|:.||..|
  Fly    72 SIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERR 136

  Fly   133 SKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPI--VEVRDILARFTTDVIGTCAFGIEC 195
            ::::...::.::|..:|..::|..:|:|...:....:|.  :..:|:...:||:||..|..||..
  Fly   137 AEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISA 201

  Fly   196 SSLKDPEAEFRVMGRRAIFEQRHGPIGIAFI-NSFQNLARRLHMKITLEEAEHFFLRIVRETVAF 259
            .|..|.......|.:| :|||..|.|....: |.:..:.:...:.:..::...||..::::.:..
  Fly   202 QSFTDNPTPMVGMTKR-VFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQKCIQV 265

  Fly   260 REKNNI--RRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALY 322
            |.::..  :|:||::.::.|:          |...|...|:.:....|...||||::..:...|.
  Fly   266 RRESPAAQQRDDFLNYMLQLQ----------EKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLL 320

  Fly   323 ELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEV 387
            .||::...|.::|:|    ||  ..|:|:|.:.::.:.:..|.||||:::.:....:...|..|:
  Fly   321 FLARNPKEQMKLREE----IG--TAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCEL 379

  Fly   388 PGHPKYVIK--KGMPVLIPCGAMHRDEKLYANPNTFNPD---NFSPERVKERDSVEWLPFGDGPR 447
            .......:|  .|..|:||..|:|.|.:.|..|.:|.|:   |.:....|.||...:..||||||
  Fly   380 TNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPR 444

  Fly   448 NCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLK-VER 503
            .|.||||...|.::.|..::..|...|..:|..........|:.:.:.|::|. |||
  Fly   445 ICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKGGVWLDFVER 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	116/477 (24%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	114/458 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460944
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900