DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	122/495 - (24%)
Similarity:	225/495 - (45%)	Gaps:	77/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNK 101
            ||..:.:.||:  :|.|.....|:         ||     |  .|.|.:...:..|.:::...:.
  Rat    71 EEGLLYIQSLS--RTFRDVCCWWV---------GP-----W--HPVIRIFHPAFIKPVILAPASV 117

  Fly   102 F-TDRGFYHNTEDDPLSGQ-LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQ 164
            . .||.||...:  |..|. |.|..|.||...|..|:..|....:|           .::::|..
  Rat   118 APKDRVFYRFLK--PWLGDGLLLSTGDKWSRHRHMLTPAFHFNILK-----------PYVKIFND 169

  Fly   165 ------------AMEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDPEAEF--RVMGRRAIFE 215
                        |.:.|..:::.:.::..|.|.:..|.|..: |:.::..:|:  .::...|:..
  Rat   170 STNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFSFD-SNCQEKPSEYITAILELSALVA 233

  Fly   216 QRHGPIGIAFINSFQNLAR-RLHMKITLEEAEHFFLRIVRE---TV-------AFREKNNIRRND 269
            :||..: :.:::.|.:|.| .:..:........|...::||   |:       |.:.|...:..|
  Rat   234 RRHQSL-LLYVDLFYHLTRDGMRFRKACRLVHDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLD 297

  Fly   270 FMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRV 334
            |:|.|:      |:|.|.||:  |:.|::.|:|..|...|.:|:::.:.:.||.||:|.:.|:|.
  Rat   298 FIDVLL------LSKDEHGEA--LSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERC 354

  Fly   335 RKECQEVI-GKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKK 397
            |:|.:|:: .:...||.::.:..:.:|...|.|:|||:.....::|.|.:|..:| |.   ||.|
  Rat   355 RQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGR---VIPK 416

  Fly   398 GMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSG 462
            |:...|.....|.:..::.:|..:||..|..:..:.|..:.::||..|||||||..|...:.:..
  Rat   417 GVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVA 481

  Fly   463 LALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            |||.:.||:  |......|  ..|...::.:|.|::|:||
  Rat   482 LALTLLRFR--VLPDDKEP--RRKPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	119/490 (24%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	117/488 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900