Protein Alignment Cyp6a9 and Cyp4a12a

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 546
• Identity: 137/546 - (25%)
• Similarity: 223/546 - (40%)
• Gaps: 94/546 - (17%)

  Fly     2 GVYSVLLAIVVVLVGYLLLKWRRALHY----W---QNLDIPCEEPHILMGS-----------LTG 48
            |..|..|.:..|| ..|||.::.|..|    |   .....|....|.|.|.           ||.
Mouse    13 GSISEYLQVASVL-SLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTR 76

  Fly    49 VQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTED 113
            ::...|....|:                |..:..|.|.|....||||.:...|  ..|.|....
Mouse    77 IKNFPSACPQWL----------------WGSKVRIQVYDPDYMKLILGRSDPK--ANGSYRFLA- 122

  Fly   114 DPLSGQ-LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDI 177
             |..|: |.:||||.|...|..|:..|....:|.....:.......::.:.|.:.:...:|:...
Mouse   123 -PWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRH 186

  Fly   178 LARFTTDVIGTCAFGIECSSLKD----------PEAEFRVMGR-RAIFEQR-------------H 218
            :...|.|.|..|||..|.|...|          .:....|..| |.||.|.             :
Mouse   187 ITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKAN 251

  Fly   219 GPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLT 283
            ....:|..::.|.:..|   :|.|::.|        |....::|   ||.||:|.|:      ..
Mouse   252 SACKLAHDHTDQVIKSR---RIQLQDEE--------ELEKLKKK---RRLDFLDILL------FA 296

  Fly   284 KSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGE 348
            :.|:|:|  |:.:::.|:...|...|.:|:::.:.:..|.||.:.:.|.|.|||.|.::|. ...
Mouse   297 RMENGKS--LSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGD-GTS 358

  Fly   349 ITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEK 413
            ||:..:..|.|....|.|.||:|..:|.::||.......|....  :.||:.|::....:|.:..
Mouse   359 ITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS--LPKGIHVMLSFYGLHHNPT 421

  Fly   414 LYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQT 478
            ::.||..|:|..|:|.  ..|.|..:|||..|.|||||.:|...:.:..:||.:.||:. :.:.|
Mouse   422 VWPNPEVFDPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPT 483

  Fly   479 TIPIVYSKKTFLISSETGIFLKVERV 504
            .:||...:  .::.|:.||.|.::::
Mouse   484 RVPIPIPR--IVLKSKNGIHLHLKKL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	116/454 (26%)
Cyp4a12a	NP_803125.2	CYP4B-like	70..503	CDD:410771	121/482 (25%)