DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	131/525 - (24%)
Similarity:	217/525 - (41%)	Gaps:	62/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VYSVLLAIVVVLVGYLLLKW-RRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKF 66
            |.:|||.:......||..:| .||..     ..|....|...|........:.|..| :.....|
  Rat    24 VLTVLLLLFKTAQFYLHRRWLLRATQ-----QFPSPPSHWFFGHKLSFLVDQEFQDI-LTRVKNF 82

  Fly    67 RGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTED-DPLSGQ-LFLLDGQKWK 129
            ....|  .:.|.....|.|.|....||||.:     :|...:|:... .|..|. |.||:||.|.
  Rat    83 PSACP--QWLWGSNVRIQVYDPDYMKLILGR-----SDPKSHHSYRFLAPWIGYGLLLLNGQTWF 140

  Fly   130 SMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIE 194
            ..|..|:..|....:|.....:.......::.:.|.:.:...:|:...:...|.|.|..|||..|
  Rat   141 QHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQE 205

  Fly   195 CSSLKDPEAE--------------FRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEA 245
            .|...|.:.:              ||:   |.||.|..      .|.|..:..|:......|..
  Rat   206 GSVQLDRKYKSYIKAVEDLNNLSFFRI---RNIFHQND------IIYSLSSNGRKARSAWQLAH- 260

  Fly   246 EHFFLRIVRETVAFREKNNI------RRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFV 304
            ||....|.......:::..:      ||.||:|.|:      ..:.|:|.|  |:.:::.|:...
  Rat   261 EHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILL------FARIENGSS--LSDKDLRAEVDT 317

  Fly   305 FFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLR 369
            |...|.:|:::.:.:..|.||.:.:.|...|||.|.::|. ...||::.:..|.|....|.|.||
  Rat   318 FMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGD-GASITWDDLDKMPYTTMCIKEALR 381

  Fly   370 LYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKER 434
            :|..:..::|........|....  :.||:.|::....:|.:..::.||..|:|..|:||  ..|
  Rat   382 IYPPVTAVSRMLSTPVTFPDGRS--LPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPE--SSR 442

  Fly   435 DSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFL 499
            .|..:|||..|.|||||.:|...:.:..:||.:.||:. :.:.|.|||...:  .::.|:.||:|
  Rat   443 HSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIPIPIPR--LVLKSKNGIYL 504

  Fly   500 KVERV 504
            :::::
  Rat   505 RLKKL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	121/485 (25%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	118/466 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900