DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	154/517 - (29%)
Similarity:	258/517 - (49%)	Gaps:	58/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLV-GYLLLKWRRALHYWQNLDIPCEEPHILMGSLTG---------VQTSRSFSAIWM 60
            ||||:|:||: |:    ..|....::...||..:|....|::..         |:..:.:..||
  Rat    13 VLLAVVLVLLYGF----GTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDVECHKKYGKIW- 72

  Fly    61 DYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLF 121
                     |.|.|    |.|...:.|..:.|.:|:|| |:.||:|     .:..|   :...:.
  Rat    73 ---------GLFDG----QMPLFAITDTEMIKNVLVKECFSVFTNR-----RDFGPVGIMGKAIS 119

  Fly   122 LLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVI 186
            :...::||..|:.||.|||||::|.|||.:.:.|...::...|  ||...|.|:::...::.|||
  Rat   120 VSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQ--EKGKPVPVKEVFGAYSMDVI 182

  Fly   187 GTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFI------NSFQNLARRLHMKITLEEA 245
            .:.:||:...||.:|:..|....::.:......|:.::.:      ..::.|...:..|.::|..
  Rat   183 TSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFF 247

  Fly   246 EHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGES-VNLTIEEMAAQAFVFFGAG 309
            :.|..|:....:...:|:.:   ||:..:::..|.    |:..|| ..|:..|:.||:.:|..||
  Rat   248 KKFVYRMKETRLDSVQKHRV---DFLQLMMNAHND----SKDKESHTALSDMEITAQSIIFIFAG 305

  Fly   310 FETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVL 374
            :|.:|:|:.|.|:.||.|.|.|.::::|....:.. ....||:::.:|.|||.|::||||||.:.
  Rat   306 YEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPN-KAPPTYDTVMEMEYLDMVLNETLRLYPIG 369

  Fly   375 PVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEW 439
            ..|.|.|.:|.|:.|   ..:.||..|:||..|:|||.:.:..|..|.|:.||.|.....|...:
  Rat   370 NRLERVCKKDVEING---VFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVY 431

  Fly   440 LPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            ||||:||||||||||..|..:..|..::..|.|..|::|.||:..|::. |:.....|.|||
  Rat   432 LPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQG-LLQPTKPIILKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	141/483 (29%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	142/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870