DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	151/509 - (29%)
Similarity:	260/509 - (51%)	Gaps:	41/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWM---DYYNKFR 67
            ||||..::|. |:...:...|  ::.|.||..:|..|.|::....     ..:|.   |.|.|:
  Rat    13 VLLATSLMLF-YIYGTYSHGL--FKKLGIPGPKPVPLFGTIFNYG-----DGMWKFDDDCYKKY- 68

  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDG 125
              |...|||...:|.:.::|..:.|::|:|| ::.||:|      ||        :...:.:.:.
  Rat    69 --GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGF--------MKKAITMSED 123

  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCA 190
            ::||.:|:.||.||||||:|.|||.:.:.|...::...:...|...:.::||...::.|||...:
  Rat   124 EEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTS 188

  Fly   191 FGIECSSLKDPEAEFRVMGRRAIFEQRHGP--IGIAFINSFQNLARRLHMKITLEEAEHFFLRIV 253
            ||:...||.:|:..|....::.:..|...|  :.:........:...|:..|...::.:||.:.|
  Rat   189 FGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFV 253

  Fly   254 RETVAFR-EKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTM 317
            :.....| :.|...|.||:..:::.:||...:|:..    |:..||||||.:|...|::.:||::
  Rat   254 KTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKA----LSDLEMAAQAIIFIFGGYDATSTSI 314

  Fly   318 GFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECL 382
            .|.:||||...::|.:::.|....:.. ...:||:::.:|.|||.|::|:||||.:...|:|...
  Rat   315 SFIMYELATRPNVQKKLQNEIDRALPN-KAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSK 378

  Fly   383 EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPR 447
            :|.|:.|   ..|.||..|.||...:||:.:.:..|..|||:.||.|.....|...:||||:|||
  Rat   379 KDVEING---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPR 440

  Fly   448 NCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            |||||||..:..:..:..::..|....||:|.||:..|::. :...|..|.||:
  Rat   441 NCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQP-IFQPEGPIILKL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	140/476 (29%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	133/444 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770