DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	228/554 - (41%)	Gaps:	121/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVY-SVLLAIVVVLVGYLLL----KWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAI-- 58
            :|:: ||::.:|:||..:.||    |..||:.     ..|....|.|.|....:|...|...:
  Rat    13 LGLWASVVILMVIVLKLFSLLLRRQKLARAMD-----SFPGPPTHWLFGHALEIQKLGSLDKVVS 72

  Fly    59 WMDYYNKFRGTGPFAGFYWF-QRPGIL-VLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQ-- 119
            |...:       |.|...|| |..|.| :.:...||.:.        .||       ||.:..
  Rat    73 WAQQF-------PHAHPLWFGQFVGFLNIYEPDYAKAVY--------SRG-------DPKAADVY 115

  Fly   120 ----------LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAM-------- 166
                      |.:|||.||...|..|:..|....:|           .::.:|.::.
  Rat   116 DFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLK-----------PYVAIFAESTRMMLDKWE 169

  Fly   167 EKSPIVEVRDI---LARFTTDVIGTCAFGIECSSL--KDPEAEFRVMGRRAIFEQRHGPIGIAFI 226
            :|:...:..||   :.....|.:..|.||...|.|  :|......|.....:.:||        |
  Rat   170 KKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQR--------I 226

  Fly   227 NSFQNLARRLHMKITLEEAEH--FFLR-----------IVRETVAF------REKNNIRRN-DFM 271
            :|||     .|.........|  .|||           ::|:..|.      |:|...||: ||:
  Rat   227 DSFQ-----YHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFL 286

  Fly   272 DQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRK 336
            |.|:.:::      |||  :.|:..|:.|:...|...|.:|:::.:.:.||.:|.:.:.|...|:
  Rat   287 DILLGVRD------ESG--IKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCRE 343

  Fly   337 ECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYE-VPGHPKYVIKKGMP 400
            |.:.::|..: ...::.:..|.||...:.|..|||..:|.:.|:..:... |.|..   :..|..
  Rat   344 EVRGILGDQD-SFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRS---LPAGSL 404

  Fly   401 VLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLAL 465
            :.:...|:||:..::.:|..|:|..||||....|....::||..|||||||.:|...:.:...||
  Rat   405 ISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTAL 469

  Fly   466 LINRFKFSVCEQTTIPIVYSKKTFLISSETGIFL 499
            .:.||:||: :.:.:||...:  .::.|:.||.|
  Rat   470 CLLRFEFSL-DPSKMPIKVPQ--LILRSKNGIHL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	123/513 (24%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	123/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900