Protein Alignment Cyp6a9 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 132/527 - (25%)
• Similarity: 221/527 - (41%)
• Gaps: 72/527 - (13%)

  Fly     5 SVLLAIVVVLVGYLLLKWR-RALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAI-WMDYYNKFR 67
            |:||..|:.|  |...:|. ||||.:     |....|...|       .:.|..: ..:.|:|..
Human    23 SLLLFQVIRL--YQRRRWMIRALHLF-----PAPPAHWFYG-------HKEFYPVKEFEVYHKLM 73

  Fly    68 ---------GTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLL 123
                     ..|||..|:       .|.|...||::|.::..|   ....|...:..:...|..|
Human    74 EKYPCAVPLWVGPFTMFF-------SVHDPDYAKILLKRQDPK---SAVSHKILESWVGRGLVTL 128

  Fly   124 DGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGT 188
            ||.|||..|..:...|....:|.....:.:.....:..:.:.:.::..:|:...::..|.|.|..
Human   129 DGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMK 193

  Fly   189 CAF----GIECSSLKDPEAEFRVMGRRAIFEQR------HGPIGIAFINS---FQNLARRLHM-- 238
            |||    .|:..|..|...: .|.....|..||      |..:...|.:.   |....:.||.
Human   194 CAFSHQGSIQLDSTLDSYLK-AVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257

  Fly   239 -KITLEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQA 302
             |:..:..|....::.::|.   :|   ||.||:|.|:..|        |..:.:.:..::.|:.
Human   258 EKVIQDRKESLKDKLKQDTT---QK---RRWDFLDILLSAK--------SENTKDFSEADLQAEV 308

  Fly   303 FVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISET 367
            ..|..||.:|:|:.:.:.||.||::.:.|.|.|.|.:|::|. ...||:|.:..|.|....|.|.
Human   309 KTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD-GSSITWEHLSQMPYTTMCIKEC 372

  Fly   368 LRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVK 432
            ||||.  ||:|...|.|..:.......:..|:.|.|...|:|.:...:.:|..|||..||.|..:
Human   373 LRLYA--PVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSE 435

  Fly   433 ERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGI 497
            :.....::||..|.|||||..|..::.:..:||.:.|||.:. :.:..|  ...:..::.|:.||
Human   436 KIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP-DHSRPP--QPVRQVVLKSKNGI 497

  Fly   498 FLKVERV 504
            .:..::|
Human   498 HVFAKKV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	113/445 (25%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	116/464 (25%)