DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a9 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	235/514 - (45%)
Similarity:	328/514 - (63%)	Gaps:	40/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70
            :|.:::..|:|||    |....||:...||...||.|.|....:| |..:|.:..:.|:.|||:.
  Fly     7 LLTSLLSFLLGYL----RYRFTYWELRGIPQLRPHFLFGHFFRLQ-SVHYSELLQETYDAFRGSA 66

  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSKL 135
            ..||.|.|.||..:|||:.|.|.:||::||.|.||..:|.   |||:..||.|.|::|:::|:||
  Fly    67 KVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDRRSFHG---DPLTANLFNLQGEEWRNLRTKL 128

  Fly   136 SYTFTSGKMKYMFPTVVKV----GHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECS 196
            |.|||||||||||.||..|    |..|.|:.|   .:..::|:.|::||:||||||:||||.|||
  Fly   129 SPTFTSGKMKYMFGTVSTVAQQLGGTFDELVG---SQGAVLELHDLMARYTTDVIGSCAFGTECS 190

  Fly   197 SLKDPEAEFRVMGRRAIFEQRHGPI-----GIAFINSFQNL---ARRLHMKITLEEAEHFFLRIV 253
            ||::|:||||.:||| ||...:..|     .:.:::|...|   .|.||..||     .||.|||
  Fly   191 SLREPQAEFRQVGRR-IFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDIT-----KFFNRIV 249

  Fly   254 RETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMG 318
            ||||..||:.|||||||||.|:||:     :.|:|:  .||:|:|||||||||.|||||||:.|.
  Fly   250 RETVELRERENIRRNDFMDLLLDLR-----RQENGK--GLTMEQMAAQAFVFFVAGFETSSSNMS 307

  Fly   319 FALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLE 383
            :||:|||::||:|.::|.|..:.|||: |::|||:|.:|.||||.|:||||.|..|..|.|...|
  Fly   308 YALFELAKNQDVQQKLRMEINDSIGKH-GKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASE 371

  Fly   384 DYEVP---GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDG 445
            |||:|   |....|::||..|.||..|:|.|.::|..|:.|.|:.|:|:..:||....:|.||||
  Fly   372 DYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDG 436

  Fly   446 PRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVERV 504
            ||||||:|||:||.:.||..|:.||:||:...:...:..:|:..::....|:.|:|:.|
  Fly   437 PRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQVDPV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	223/478 (47%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	224/480 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970