DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	157/545 - (28%)
Similarity:	258/545 - (47%)	Gaps:	108/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLTGVQ---------TSRSFSAIWM 60
            :|||.::||: ||   :..:.| .::.|.|...:|...:|::...:         ..:.:..||
  Rat    13 MLLATILVLL-YL---YGTSTHGNFKKLGISGPKPLPFVGNILAYRHGFWEFDRHCHKKYGDIW- 72

  Fly    61 DYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLF 121
                         |||..::|.:.:.|..:.|.:|:|| ::.||:|..:     .|   |...:.
  Rat    73 -------------GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF-----GPAGILKKAIT 119

  Fly   122 LLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVI 186
            |.:.::||.:|:.||.||||||:|.|||.:.:.....::......||...:.::||...::.|||
  Rat   120 LSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVI 184

  Fly   187 GTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLR 251
            ...:||:...||.:|:                        |.|....::|   :.....:.|||.
  Rat   185 TGTSFGVNVDSLNNPQ------------------------NPFVQKVKKL---LKFNFLDPFFLS 222

  Fly   252 IV-------------------------RETVAFREKNNI-----RRNDFMDQLIDLKNSPLTKSE 286
            ::                         |.:|...::|.:     :|.||:..:|:.::|...:|.
  Rat   223 VILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDKESH 287

  Fly   287 SGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITY 351
            .|    ||..|:.||:..|..||:||:|:.:.||||.||.|.|:|.:::.|....:.. ...:||
  Rat   288 QG----LTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAALPN-KAPVTY 347

  Fly   352 ESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYA 416
            :.:.:|.|||.|::|||||:.|...|.|.|.:|.|:.|   ..|.||..|::|..|:|:|.|.:.
  Rat   348 DVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEING---VFIPKGTVVMVPTFALHKDPKCWP 409

  Fly   417 NPNTFNPDNFSPERVKERDSVE---WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQT 478
            .|..|.|:.|   |.|.:||:.   :||||:||||||||||..|..:..|..::..|.|.:|::|
  Rat   410 EPEEFCPERF---RKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKET 471

  Fly   479 TIPIVYSKKTFLISSETGIFLKVER 503
            .||:...||.|....:..|...|.|
  Rat   472 QIPLKLRKKGFFQPEKPIILRAVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	145/509 (28%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	144/508 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770