Protein Alignment Cyp6a9 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 157/545 - (28%)
• Similarity: 258/545 - (47%)
• Gaps: 108/545 - (19%)

  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLTGVQ---------TSRSFSAIWM 60
            :|||.::||: ||   :..:.| .::.|.|...:|...:|::...:         ..:.:..||
  Rat    13 MLLATILVLL-YL---YGTSTHGNFKKLGISGPKPLPFVGNILAYRHGFWEFDRHCHKKYGDIW- 72

  Fly    61 DYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLF 121
                         |||..::|.:.:.|..:.|.:|:|| ::.||:|..:     .|   |...:.
  Rat    73 -------------GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF-----GPAGILKKAIT 119

  Fly   122 LLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVI 186
            |.:.::||.:|:.||.||||||:|.|||.:.:.....::......||...:.::||...::.|||
  Rat   120 LSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVI 184

  Fly   187 GTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLR 251
            ...:||:...||.:|:                        |.|....::|   :.....:.|||.
  Rat   185 TGTSFGVNVDSLNNPQ------------------------NPFVQKVKKL---LKFNFLDPFFLS 222

  Fly   252 IV-------------------------RETVAFREKNNI-----RRNDFMDQLIDLKNSPLTKSE 286
            ::                         |.:|...::|.:     :|.||:..:|:.::|...:|.
  Rat   223 VILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDKESH 287

  Fly   287 SGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITY 351
            .|    ||..|:.||:..|..||:||:|:.:.||||.||.|.|:|.:::.|....:.. ...:||
  Rat   288 QG----LTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAALPN-KAPVTY 347

  Fly   352 ESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYA 416
            :.:.:|.|||.|::|||||:.|...|.|.|.:|.|:.|   ..|.||..|::|..|:|:|.|.:.
  Rat   348 DVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEING---VFIPKGTVVMVPTFALHKDPKCWP 409

  Fly   417 NPNTFNPDNFSPERVKERDSVE---WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQT 478
            .|..|.|:.|   |.|.:||:.   :||||:||||||||||..|..:..|..::..|.|.:|::|
  Rat   410 EPEEFCPERF---RKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKET 471

  Fly   479 TIPIVYSKKTFLISSETGIFLKVER 503
            .||:...||.|....:..|...|.|
  Rat   472 QIPLKLRKKGFFQPEKPIILRAVSR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	140/466 (30%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	143/481 (30%)