Protein Alignment Cyp6a9 and CYP3A5

DIOPT Version :9

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 168/519 - (32%)
• Similarity: 266/519 - (51%)
• Gaps: 60/519 - (11%)

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIW---MDYYNKFR 67
            :|||:.:||   |.|...|....::.|.||...|..|:|::...:     ..:|   .:.|.|:
Human    13 LLLAVSLVL---LYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-----QGLWKFDTECYKKY- 68

  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDG 125
              |...|.|..|.|.:.:.|..:.:.:|:|| ::.||:|      ||        :...:.|.:.
Human    69 --GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF--------MKSAISLAED 123

  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCA 190
            ::||.:||.||.||||||:|.|||.:.:.|...:....:..||...|.::||...::.|||...:
Human   124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188

  Fly   191 FGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFIN---------SFQNLARRLHMKITLEEAE 246
            ||:...||.:|:..|....::.:   :.|.:...|::         .|:.|...|..|.|:....
Human   189 FGVNIDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLS 250

  Fly   247 HFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFE 311
            ....|:.:..:..::|:   |.||:..:||.:||..|:|...    |:..|:|||:.:|..||:|
Human   251 KSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNSKETESHKA----LSDLELAAQSIIFIFAGYE 308

  Fly   312 TSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPV 376
            |:|:.:.|.|||||.|.|:|.:::||...|:.. ....||:::..|.|||.|::|||||:.|...
Human   309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN-KAPPTYDAVVQMEYLDMVVNETLRLFPVAIR 372

  Fly   377 LNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE--- 438
            |.|.|.:|.|:.|   ..|.||..|:||..|:|.|.|.:..|..|.|:.||    |::||::
Human   373 LERTCKKDVEING---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS----KKKDSIDPYI 430

  Fly   439 WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            :.|||.||||||||||..|..:..|..::..|.|..|::|.||:....:. |:..|..|.|||:
Human   431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	155/485 (32%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	156/487 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720