DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a9 and CYP3A4

DIOPT Version :9

Sequence 1:NP_523748.2 Gene:Cyp6a9 / 36663 FlyBaseID:FBgn0013771 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:525 Identity:163/525 - (31%)
Similarity:262/525 - (49%) Gaps:71/525 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70
            :|||:.:||: ||.......|  ::.|.||...|...:|::  :...:.|....|:.:.|:   |
Human    13 LLLAVSLVLL-YLYGTHSHGL--FKKLGIPGPTPLPFLGNI--LSYHKGFCMFDMECHKKY---G 69

  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDGQKW 128
            ...|||..|:|.:.:.|..:.|.:|:|| ::.||:|      ||        :...:.:.:.::|
Human    70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF--------MKSAISIAEDEEW 126

  Fly   129 KSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGI 193
            |.:||.||.||||||:|.|.|.:.:.|...:....:..|....|.::|:...::.|||.:.:||:
Human   127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191

  Fly   194 ECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITL---------------- 242
            ...||.:|:..|        .|.....:...|::.|       .:.||:                
Human   192 NIDSLNNPQDPF--------VENTKKLLRFDFLDPF-------FLSITVFPFLIPILEVLNICVF 241

  Fly   243 -EEAEHFFLRIVRETVAFR-EKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVF 305
             .|..:|..:.|:.....| |.....|.||:..:||.:||..|:|...    |:..|:.||:.:|
Human   242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA----LSDLELVAQSIIF 302

  Fly   306 FGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRL 370
            ..||:||:|:.:.|.:||||.|.|:|.::::|...|:.. ....||:::..|.|||.|::|||||
Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLRL 366

  Fly   371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERD 435
            :.:...|.|.|.:|.|:.|   ..|.||:.|:||..|:|||.|.:..|..|.|:.||.   |.:|
Human   367 FPIAMRLERVCKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK---KNKD 425

  Fly   436 SVE---WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGI 497
            :::   :.|||.||||||||||..|..:..|..::..|.|..|::|.||:..|... |:..|..:
Human   426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPV 489

  Fly   498 FLKVE 502
            .||||
Human   490 VLKVE 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a9NP_523748.2 p450 35..499 CDD:278495 149/491 (30%)
CYP3A4NP_059488.2 p450 39..493 CDD:365848 150/493 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 1 1.000 - - mtm8447
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.820

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