Protein Alignment Cyp6a9 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 160/516 - (31%)
• Similarity: 265/516 - (51%)
• Gaps: 53/516 - (10%)

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70
            :|||:.::|   |.|...|....::.|.||...|...:|:  .:...:.:....|:.|.|:|...
Human    13 LLLAVSLIL---LYLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDMECYKKYRKVW 72

  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDGQKW 128
               |.|..|:|.:.:.|..:.|.:|:|| ::.||:|      ||..|.        :.:.:.::|
Human    73 ---GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNA--------ISIAEDEEW 126

  Fly   129 KSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGI 193
            |.:||.||.||||||:|.|.|.:.:.|...:....:..|....|.::.:...::.|||.:.:||:
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191

  Fly   194 ECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQ------NLARRLHMKITLEEAEHFFLRI 252
            ...||.:|:..|....::.:   |..|:. .|:.|.:      .:...|::.:...:...|..:.
Human   192 SIDSLNNPQDPFVENTKKLL---RFNPLD-PFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252

  Fly   253 VRETVAFREKNNIR-RNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTT 316
            |::....|.|...: |.||:..:||.:||  ..||:.::  |:..|:.||:.:|..||:||:|:.
Human   253 VKQIKEGRLKETQKHRVDFLQLMIDSQNS--KDSETHKA--LSDLELMAQSIIFIFAGYETTSSV 313

  Fly   317 MGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNREC 381
            :.|.:||||.|.|:|.:|:||...|:.. ....||:::..:.|||.|::|||||:.|...|.|.|
Human   314 LSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVC 377

  Fly   382 LEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE---WLPFG 443
            .:|.|:.|   ..|.||:.|:||...:|.|.|.:..|..|.|:.||.   |.:|:::   :.|||
Human   378 KKDVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSK---KNKDNIDPYIYTPFG 436

  Fly   444 DGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTF--LISSETGIFLKVE 502
            .||||||||||..:..:..|..::..|.|..|::|.||:   |..|  |:.:|..|.||.|
Human   437 SGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL---KLRFGGLLLTEKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	140/448 (31%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	143/453 (32%)