DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	513	Identity:	164/513 - (31%)
Similarity:	264/513 - (51%)	Gaps:	48/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLTGVQTSRSFSAIW---MDYYNKF 66
            |||||::|    ||.::....| .::...||..:|...:|::...     :..:|   |:.|.|:
Mouse    13 VLLAIILV----LLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNY-----YKGLWKFDMECYEKY 68

  Fly    67 RGT-GPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR-GFYHNTEDDP---LSGQLFLLDG 125
            ..| |.|.|    |.|..::.|....|.:|:|| |:.||:| .|:      |   :|..:.|...
Mouse    69 GKTWGLFDG----QIPLFVITDPETIKNVLVKECFSVFTNRQDFF------PVGIMSKSISLAKD 123

  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCA 190
            ::||..|:.||.|||||.:|.|||.:.:.|...::...|..||...|.|:|:|..::.|||.:..
Mouse   124 EEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTT 188

  Fly   191 FGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIA-----FINS-FQNLARRLHMKITLEEAEHFF 249
            ||:...||.:||..|....::.:......|:.::     |:.. ::.|...:..|.::|..:.|.
Mouse   189 FGVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFV 253

  Fly   250 LRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIE-EMAAQAFVFFGAGFETS 313
            .|:....:..::|:.:   ||:..:::..|    ||:..:|.....| |:.||:.:|..||:||:
Mouse   254 DRMTENRLDSKQKHRV---DFIYLMMEAYN----KSKDKDSHKALSEIEITAQSIIFIFAGYETT 311

  Fly   314 STTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLN 378
            |:.:.|.:|.||.|.|||.::::|..|.:.. ....||:::..|.|||.|::||||||.:...|.
Mouse   312 SSILSFTVYSLATHPDIQKKLQEEIDEALPN-KAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQ 375

  Fly   379 RECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFG 443
            |.|.:|.|:.|   ..|.||..|:||...:|.|.:.:..|..|.|:.||.|.....|...:||||
Mouse   376 RVCKKDVEING---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFG 437

  Fly   444 DGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            :||||||||||..|..:..|..::..|.|..|::|.||:..|:: .|:.....|.|||
Mouse   438 NGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRE-LLLQPVKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	151/479 (32%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	152/481 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720