DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	507	Identity:	154/507 - (30%)
Similarity:	255/507 - (50%)	Gaps:	37/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70
            :|||..:||   |.|....:...::.|.||..:|...:|::...|  :.|....:..:.|:   |
Mouse    13 MLLATSLVL---LYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQ--KGFWECDIQCHKKY---G 69

  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLFLLDGQKWKSM 131
            ...|.|..::|.:.:.|..:.|.:|:|| ::.||:|..:     .|   |...:.:.:.::||.:
Mouse    70 KMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF-----GPVGILKKAISISENEEWKRI 129

  Fly   132 RSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGIECS 196
            |:.||.|||||::|.|||.:.:.....:....|.:.:.....::||...::.|||...:||:...
Mouse   130 RALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNID 194

  Fly   197 SLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLA---RRLHMKITLEEAEHFFLRIVRETVA 258
            ||.:|:..|....::.:......|:.:: :..|..|.   ..|::.:...:...||...|.....
Mouse   195 SLNNPQDPFVEKIKKLLKFDIFDPLFLS-VTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKE 258

  Fly   259 FREKNNIR-RNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALY 322
            .|.|...: |.||:..:|:.:|....:|...    |:..|:.||:.:|..||:||:|:.:.||||
Mouse   259 NRMKEKEKQRVDFLQLMINSQNYKTKESHKA----LSDVEIVAQSVIFIFAGYETTSSALSFALY 319

  Fly   323 ELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEV 387
            .||.|.|:|.:::.|....:.. ....||:::..|.|||.|::||||||.:...|.|.|..|.|:
Mouse   320 LLAIHPDVQKKLQDEIDAALPN-KAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEI 383

  Fly   388 PGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE---WLPFGDGPRNC 449
            .|   ..|.||..|:||..|:|:|.|.:..|..|.|:.||.   |.:||:.   :||||.|||||
Mouse   384 NG---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSK---KNQDSINPYMYLPFGSGPRNC 442

  Fly   450 IGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            |||||..:..:..|..::..|....|::|.||:..||:. |:..|..:.|||
Mouse   443 IGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQG-LLQPENPLLLKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	142/474 (30%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	142/474 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710