Protein Alignment Cyp6a9 and CYP4F22

DIOPT Version :9

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 128/571 - (22%)
• Similarity: 237/571 - (41%)
• Gaps: 137/571 - (23%)

  Fly     3 VYSV--LLAIVVVLVGYLLLKWRRALHYWQNLDIPCE------EP---HILMGSL-------TGV 49
            :|:|  ||..::..:..|||   |.|...::..|.|.      :|   :.|:|.|       .|:
Human    21 IYAVSTLLLFLLFFLFRLLL---RFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGL 82

  Fly    50 QTSRS-------FSAIWM------------DYYNKFRGTGPFAG-----FYWFQRPGILVLDISL 90
            |..:.       ...:||            ||.....|......     ||.|.:|.
Human    83 QDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPW-------- 139

  Fly    91 AKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVG 155
                                     |...|.|..|.||...|..|:..|....:|
Human   140 -------------------------LGDGLLLSKGDKWSRHRRLLTPAFHFDILK---------- 169

  Fly   156 HEFIEVFGQA-----------MEKSPI-VEVRDILARFTTDVIGTCAFGIECSSLKDPEAEF--R 206
             .::::|.|:           .|.|.: :::.:.::..|.|.:..|.|... |:.::..:::  .
Human   170 -PYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN-SNCQEKMSDYISA 232

  Fly   207 VMGRRAIFEQR----HGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIVRE---------TVA 258
            ::...|:..:|    |..:...:..|..  .||...  ..:...||...:::|         ..|
Human   233 IIELSALSVRRQYRLHHYLDFIYYRSAD--GRRFRQ--ACDMVHHFTTEVIQERRRALRQQGAEA 293

  Fly   259 FREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYE 323
            :.:....:..||:|.|:      |.:.|.|:  .|:.|::.|:|..|...|.:|:|:.:.:.|:.
Human   294 WLKAKQGKTLDFIDVLL------LARDEDGK--ELSDEDIRAEADTFMFEGHDTTSSGISWMLFN 350

  Fly   324 LAQHQDIQDRVRKECQEVI-GKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEV 387
            ||::.:.|::.|:|.|||: |:...|:.::.:..:.:....|.|:||.|..:.:::|:|.||.::
Human   351 LAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKL 415

  Fly   388 P-GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIG 451
            | |.   :|.||:..|:.....|.:..::.:...:||..|.|:..::|..:.::||..|||||||
Human   416 PDGR---IIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIG 477

  Fly   452 MRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            ..|...:.|..:||.:.||:.|| ::|.  .|..|...::.:|.|::||||
Human   478 QSFAMAELRVVVALTLLRFRLSV-DRTR--KVRRKPELILRTENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	114/532 (21%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	114/526 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900