Protein Alignment Cyp6a9 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 135/549 - (24%)
• Similarity: 236/549 - (42%)
• Gaps: 105/549 - (19%)

  Fly     8 LAIVVVLVGYLL---LKWRRALHYWQNLDIPC----EEPHILMGSLTGVQTS-----RSFSAIWM 60
            |.::||...:||   |.|..|. |.....:.|    .:.:..:|.| |:.|.     |..:.:..
Human    20 LLLLVVGASWLLARILAWTYAF-YHNGRRLRCFPQPRKQNWFLGHL-GLVTPTEEGLRVLTQLVA 82

  Fly    61 DYYNKF-RGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLD 124
            .|...| |..||.........|.|:...|:.:..|..|:.       .::.|....|...|.|..
Human    83 TYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDI-------VFYKTLKPWLGDGLLLSV 140

  Fly   125 GQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQ------------AMEKSPIVEVRDI 177
            |.||:..|..|:..|....:|           .:|::|.:            |||.|..::|.:.
Human   141 GDKWRHHRRLLTPAFHFNILK-----------PYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEH 194

  Fly   178 LARFTTDVIGTCAFGIECSSLKDPEAEF--RVMGRRAIFEQRHG-------------PIGIAFIN 227
            ::..|.|.:..|.|..: |:.::..:|:  .:|...|:..:|:.             |.|
Human   195 ISLMTLDSLQKCIFSFD-SNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCG----- 253

  Fly   228 SFQNLARRLHMKITLEEAEHFFLRIV----RETVA-------FREKNNIRRNDFMDQLIDLKNSP 281
                  ||.|....|   .|.|...|    |.|:.       .:.|...:..||:|.|:
Human   254 ------RRFHRACRL---VHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLL------ 303

  Fly   282 LTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVI-GKY 345
            |::.::|:  .|:.|::.|:|..|...|.:|:::.:.:.||.||:|.:.|:|.|:|.||:: .:.
Human   304 LSEDKNGK--ELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRE 366

  Fly   346 NGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHR 410
            ..||.::.:..:.:|...:.|:|||:..:|...|.|.:|..:|  ...||.||....|...|:|.
Human   367 PKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLP--DSRVIPKGNVCNINIFAIHH 429

  Fly   411 DEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKF--S 473
            :..::.:|..::|..|.||..::|..:.::||..|||||||.:|...:.:..|||.:.||:.  .
Human   430 NPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD 494

  Fly   474 VCEQTTIPIVYSKKTFLISSETGIFLKVE 502
            ..|....|.:      ::.:|.|::|:||
Human   495 HREPRRTPEI------VLRAEDGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	114/470 (24%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	118/489 (24%)