Protein Alignment Cyp6a9 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 130/520 - (25%)
• Similarity: 218/520 - (41%)
• Gaps: 94/520 - (18%)

  Fly     6 VLLAIVVVLV-GYLLLKWRRALHYWQNLDIPCEEPHILMGSL--------TGVQTSRSFSAIWMD 61
            :||...|:|. |.......||...::::..| ..|..|:|.|        .|   .|....:::|
Human     6 LLLGSAVLLAFGLCCTFVHRARSRYEHIPGP-PRPSFLLGHLPCFWKKDEVG---GRVLQDVFLD 66

  Fly    62 YYNKFRGTGPFAGFYWFQRPGILVLD-ISLAKLILIKEFNKFTDRGFYHNTE---DDPLSGQLFL 122
            :..|:   ||......|.:..::|.. .|:.|.::..::||  |...|...:   .:.|.||..:
Human    67 WAKKY---GPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNK--DSKMYRALQTVFGERLFGQGLV 126

  Fly   123 --LDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDV 185
              .:.::|...|..:...|:...:..:..|..:...:.:|:.....:....|.::|:|.....|:
Human   127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191

  Fly   186 IGTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFL 250
            :...|||:|.|.|         :|.:....|....:......|...||:.|       ..:...|
Human   192 LAKAAFGMETSML---------LGAQKPLSQAVKLMLEGITASRNTLAKFL-------PGKRKQL 240

  Fly   251 RIVRETVAF----------REKNNIRRN-----DFMDQLIDLKNSPLTKSESGESVNLTIEEMAA 300
            |.|||::.|          |.:..::|.     |.:.|::        |:|.|...:   |.:..
Human   241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL--------KAEEGAQDD---EGLLD 294

  Fly   301 QAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIG--KYNGEITYESMKDMVYLDQV 363
            ....||.||.|||:..:.|.:.||::..:|..|::.|..||||  :|   :.:|.:..:.||.||
Human   295 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY---LDFEDLGRLQYLSQV 356

  Fly   364 ISETLRLYT----VLPVLNRECLED-YEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNP 423
            :.|:||||.    ...:|..|.|.| ..|||:        .|:|.....|.|.:..:.:|.||||
Human   357 LKESLRLYPPAWGTFRLLEEETLIDGVRVPGN--------TPLLFSTYVMGRMDTYFEDPLTFNP 413

  Fly   424 DNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRF--------KFSVCEQTTI 480
            |.|.|...|.|  ..:.||..|.|:|||.:|.||:.:..:|.|:.|.        :|.:.||.|:
Human   414 DRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL 476

  Fly   481  480
            Human   477  476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	114/449 (25%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	116/461 (25%)