DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a9 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	519	Identity:	166/519 - (31%)
Similarity:	267/519 - (51%)	Gaps:	60/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLLAIVVVLVGYLLLKWRRALH-YWQNLDIPCEEPHILMGSLTGVQTSRSFSAIW---MDYYNKF 66
            |||||::|    ||.::....| .::...||..:|...:|::...     :..:|   |:.|.|:
Mouse    13 VLLAIILV----LLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNY-----YKGLWKFDMECYEKY 68

  Fly    67 RGT-GPFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDRGFYHNTEDDP---LSGQLFLLDGQ 126
            ..| |.|.|    |.|..::.|..:.|.:|:|| |:.||:|     .|..|   :|..:.:...:
Mouse    69 GKTWGLFDG----QMPLFVITDPEMIKNVLVKECFSVFTNR-----REFGPVGIMSKAISISKDE 124

  Fly   127 KWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAF 191
            :||..|:.||.||||||:|.|||.:.:.|...::...|..||...|.::|:|..::.|||.:.:|
Mouse   125 EWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSF 189

  Fly   192 GIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINS--------------FQNLARRLHMKITL 242
            |:...||.:||..|        .|:..|.:.:.|.:.              ::.|...:..|.::
Mouse   190 GVNVDSLNNPEDPF--------VEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSI 246

  Fly   243 EEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFG 307
            |..:.|..|:....:..::|:.:   ||:..:::..|:  :|.:..... |:..|:.||:.||..
Mouse   247 EFFKKFVNRMKESRLDSKQKHRV---DFLQLMMNAHNN--SKDKDSHKA-LSDMEITAQSIVFIF 305

  Fly   308 AGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYT 372
            ||:||:|:|:.|.||.||.|.|||.::::|..|.:.. ....||:::.:|.|||.|::||||||.
Mouse   306 AGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPN-KAPPTYDTVMEMEYLDMVLNETLRLYP 369

  Fly   373 VLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSV 437
            :...|.|.|.:|.|:.|   ..|.||..|:||..|:|.|.:.:..|..|.|:.||.|.....|..
Mouse   370 IGNRLERFCKKDVELNG---VYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPY 431

  Fly   438 EWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501
            .::|||.||||||||||..|..:..|..::..|.|..|::|.||:..|::. |:..|..|.|||
Mouse   432 LYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQG-LLQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	153/485 (32%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	154/487 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720