DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and CYP711A1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_565617.2	Gene:	CYP711A1 / 817157	AraportID:	AT2G26170	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	538	Identity:	133/538 - (24%)
Similarity:	232/538 - (43%)	Gaps:	84/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVGVLTLVAWWVLQNYTY---WKRRGIPHDPPNIPLGNTGELWRTMPLA--------GILKRTYL 61
            ::..||..| .|:..|.|   |....:| .|..:||  .|.|    ||.        .:|.:.|
plant    21 LIAFLTFAA-VVIVIYLYRPSWSVCNVP-GPTAMPL--VGHL----PLMAKYGPDVFSVLAKQY- 76

  Fly    62 KFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPL-TNNLATIEGQ 125
                   ||...|.:.....|:|.:.:..:.|.|:.|....:|.:.......|| ...|.....:
plant    77 -------GPIFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDK 134

  Fly   126 KWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICA 190
            :|..:|..:...:..:.:.|:..|:    ...|......:.|..:.:..:::..:.|:|:||..|
plant   135 RWSKMRNTILSLYQPSHLTSLIPTM----HSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAA 195

  Fly   191 FGLKC-----NSLRDPK-AEFV-QMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQKF 248
            ||:..     ..::|.: .:|: |..||..:.:     :||    ...|::.||  .|:|.:|:.
plant   196 FGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLK-----MDL----SGSLSIILG--LLIPILQEP 249

  Fly   249 Y---MKIVQDTIDYRMKRKVTR--------------------NDFMDTLIDMKQQYDKGDKENGL 290
            :   :|.:..|:|:|:::...|                    .||:..::..::. |...| |..
plant   250 FRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARES-DPFAK-NIF 312

  Fly   291 AFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLF 355
            ..:.::|..:...|||....:.|:...||.::.:.||:.:|..|||....|......:|......
plant   313 TSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFP 377

  Fly   356 YMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPE 420
            |:::||.|::|.:.|...:||...|..:...  |.:..||.|.::...:..||:.:||||||.||
plant   378 YLDQVIKEAMRFYMVSPLVARETAKEVEIGG--YLLPKGTWVWLALGVLAKDPKNFPEPEKFKPE 440

  Fly   421 RFDE--EQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHN--FRFELHPKTPVPMKYT 481
            |||.  |:.|.|...||:|||.|||.|:|.||...::.:.|..|..|  ||..|..:.|:.:.|
plant   441 RFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDY- 504

  Fly   482 INNLLLGSEGGIHLNITK 499
              .::|..:.|:.|...|
plant   505 --GIILSFKNGVKLRTIK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	124/505 (25%)
CYP711A1	NP_565617.2	cytochrome_P450	75..515	CDD:425388	115/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760