DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and tbxas1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	545	Identity:	143/545 - (26%)
Similarity:	261/545 - (47%)	Gaps:	92/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAG---ILKRTYLKFRKQTD----- 68
            |:|:.|:.:..::..:|.||.|..|             :|..|   :.:..:  |:.|.|
Zfish    29 LSLLYWYSISPFSNLERCGIKHPKP-------------LPFIGNLMMFRNGF--FKSQADLINKY 78

  Fly    69 GPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHD----RGVYHNEKDDPLTNNLATIEGQKWKN 129
            |...|:|:.....::|.|.|.::.|::::|:||.:    ||:     ..|::::|..::|::||.
Zfish    79 GRICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGI-----TKPMSDSLIMLKGEQWKR 138

  Fly   130 LRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGLK 194
            :|..||.||::||||.|...:....:.::|.: :..:.|..:..:......||.|||...|||.:
Zfish   139 VRSILTPTFSAAKMKEMVPLINTATETLLRNL-KSHAESENSFNIHKCFGCFTMDVIASVAFGTQ 202

  Fly   195 CNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLL------------PSVQK 247
            .:|..:|...||   :.|.:.....:...::||.|       .|.|||            ..:..
Zfish   203 VDSQNNPDDPFV---HQASKFFAFSFFRPIMIFFM-------AFPFLLRLLAGLLPNKSRDEMNS 257

  Fly   248 FYMKIVQDTIDYR--MKRKVTRNDFMDTLIDMK-------------------QQYD--------- 282
            |:.:.:|..|..|  :..:..|.||:..::|::                   :.||
Zfish   258 FFTQCIQKMIKQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANE 322

  Fly   283 ---KGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNG 344
               :..::..:..:|:..|:|:|.:||:|..|.|:.||.|.||.:.:.|.||:.|:|....|:.
Zfish   323 STKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHE- 386

  Fly   345 KLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPE 409
            .::|.::|:|.|::.||.||||.:|....:||...:....:.  .|:..|..:.:.|..:|:|||
Zfish   387 TVDYANVQELKYLDMVICESLRLYPPAFRVARDVEEDTVLNG--QFLPKGASLEIPTGFLHYDPE 449

  Fly   410 FYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKT 474
            .:.||.|||||||..|...:|....:||||||||:|:|:|..::::.:.|..:...|.......|
Zfish   450 HWTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDT 514

  Fly   475 PVPMKYTINNLLLGSEGGIHLNITK 499
            .:|::.. ::..||.:.|:.:.||:
Zfish   515 EIPLELK-SHTTLGPKNGVMVKITE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	135/519 (26%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	134/519 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770