DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	224/550 - (40%)	Gaps:	110/550 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPP--NIPLGNTGELWRT---MPLAGILKRTY-- 60
            :|||:...:|..:..|....|....|......||  |...|:.|.:...   |.|...:.:|:
Mouse    22 LLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGMIQSNEEGMQLVTEMGQTFQD 86

  Fly    61 ---------LKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDP-L 115
                     :...:..|..|....|.|...:...|:.|::.:                   .| |
Mouse    87 VHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFL-------------------KPWL 132

  Fly   116 TNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEK----ISSSSQTLEVTD 176
            .:.|....|.||...|:.||..|....:|    ..:.:.::.:.::..|    .|..|..||:.:
Mouse   133 GDGLFLSSGDKWSRHRRLLTPAFHFDILK----PYVKIFNQSVNIMHAKWKHLSSEGSARLEMFE 193

  Fly   177 IVSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFL 241
            .:|..|.|.:..|.||...|....| :|::    ||:.|             :..|.:|...|..
Mouse   194 HISLMTLDSLQKCLFGFDSNCQESP-SEYI----SAILE-------------LSSLIIKRSLQLF 240

  Fly   242 L-------------------PSVQKFYMKIVQD---TID-------YRMKRKVTRNDFMDTLIDM 277
            |                   ..|..|...::::   |:.       .:.|.|....||:|.|:..
Mouse   241 LFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLA 305

  Fly   278 KQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ER 341
            |.::.|     .|:..::.|:|..|...|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|
Mouse   306 KDEHGK-----ELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDR 365

  Fly   342 YNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTL 402
            ...::|:|.:..|.::...|.||||.|..|..|.|..|:    |.....||     |...::|..
Mouse   366 EPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPK-----GNICVISIF 425

  Fly   403 GIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFR 467
            ||||:|..:|:||.:.|.|||.|..:||...||:||.||||||||..|...::.:.|||.:  .|
Mouse   426 GIHHNPSVWPDPEVYDPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTL--LR 488

  Fly   468 FELHPKTPVPMKYTINNLLLGSEGGIHLNI 497
            |.:.|....|.:..  .::|.:|||:.|.:
Mouse   489 FRILPDDKEPRRKP--EIILRAEGGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	128/517 (25%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	128/516 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900