Protein Alignment Cyp6a19 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 144/588 - (24%)
• Similarity: 268/588 - (45%)
• Gaps: 120/588 - (20%)

  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN----TGELWRTMPLAGILKRTYLKF 63
            :.:.|.|.:|.|:.|:....::..::.|:.|..|:..:||    ....|.:.          ::.
Human    16 VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQ----------MEL 70

  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDR---GVYHNEKDDPLTNNLATIEGQ 125
            || ..||..|:||....:|||::.|.:|.||:.:|..|.:|   |:....    :.:::..:..:
Human    71 RK-LYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKS----VADSVLFLRDK 130

  Fly   126 KWKNLRQKLTHTFTSAKMKSMFSTVL------NVGDE---------------------------- 156
            :|:.:|..|...|:..|:..:...::      ::|.:
Human   131 RWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPF 195

  Fly   157 -MIRVVDE----------KISSSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRDPKAEFVQ--- 207
             |:.::.:          :.:.|....::......:|:||:...|||...:|.:.|:..||:
Human   196 CMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCK 260

  Fly   208 --MGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQK-----FYMKIVQDTIDYRMKR-- 263
              ..:...|.      :.:|:...|.:.|.|.  .:||:..:     |:.|::::.|..|.::
Human   261 RFFEFCIPRP------ILVLLLSFPSIMVPLA--RILPNKNRDELNGFFNKLIRNVIALRDQQAA 317

  Fly   264 KVTRNDFMDTLIDMK--------QQYD--------KGDKEN------------GLAFNEVAAQAF 300
            :..|.||:..::|.:        |.:|        .|.|.|            .|..:|:..|||
Human   318 EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAF 382

  Fly   301 VFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQD-LFYMEKVINES 364
            :|.:||:|..:.|:.|..|.||.|.|.|:||..|:|...|::... |:.|::: |.|::.||.|:
Human   383 IFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFCSLEEGLPYLDMVIAET 446

  Fly   365 LRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429
            ||.:|......|.|.:..:....:  |.||..:.::...:|||||.:|.||.|.||||..|..::
Human   447 LRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ 509

  Fly   430 RPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIH 494
            .....:||||||||:|:|:|.|.::|.:.|..::|.|||:..|:|.||::.. :...||.:.|::
Human   510 HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLE-SKSALGPKNGVY 573

  Fly   495 LNI 497
            :.|
Human   574 IKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	130/515 (25%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	130/515 (25%)