DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	550	Identity:	148/550 - (26%)
Similarity:	238/550 - (43%)	Gaps:	84/550 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GLVVGVLTLVAW---------WVLQNYTYW---------KRRGIPHDPP-NIPLGNTG------E 45
            ||.:|.:..::|         |:|.....|         :.|..|..|. |..||:.|      |
Mouse     8 GLDLGSVVTLSWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGMIEHNEE 72

  Fly    46 LWRTMPLAGILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNE 110
            ..:.|..||   :||........||       .:..:.|.|..||..:|:...........:|..
Mouse    73 GMQLMTEAG---QTYRDVHLCWLGP-------VIPVLRIVDPAFVAPLLLASALVAPKDTTFHTF 127

  Fly   111 KDDPLTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEK----ISSSSQT 171
            ....|.:.|....|.||...|:.||..|....:|    ..:.:.::.:.::..|    .|..|..
Mouse   128 VKPWLGDGLFLNSGDKWSRHRRLLTPAFHFDILK----PYVKIFNQSVNIMHAKWKHLSSEGSAR 188

  Fly   172 LEVTDIVSRFTSDVIGICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWL---VDLLIFGMPK 231
            ||:.:.:|..|.|.:..|.||...|....| :|::.  :..|:|..:|...|   ||.|.:   .
Mouse   189 LEMFEHISLMTLDSLQKCLFGFDSNCQESP-SEYISAILELSSLVIKRSHQLFLFVDFLYY---H 249

  Fly   232 LAVKLGFQFLLPSVQKFYMKIVQD---TID-------YRMKRKVTRNDFMDTLIDMKQQYDKGDK 286
            .|....|:.....|..|...::::   |:.       .:.|.|....||:|.|:..|.::.|
Mouse   250 TADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAKDEHGK--- 311

  Fly   287 ENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLE-RYNGKLEYDS 350
              .|:..::.|:|..|...|.:..::.:.:.||.||.:.:.|::.|.|:..:|. |...::|:|.
Mouse   312 --ELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDD 374

  Fly   351 MQDLFYMEKVINESLRKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTLGIHHDPEFY 411
            :..|.::...|.||||.||.|..|.|..|:    |.....||     |...::|..||||:|..:
Mouse   375 LAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPK-----GNICVISIFGIHHNPSVW 434

  Fly   412 PEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPV 476
            |:||.:.|.|||.|...|||..||:||.||||||||..|...::::.|||.:  .||.:.|....
Mouse   435 PDPEVYDPFRFDPENAHKRPPLAFIPFSAGPRNCIGQTFAMNEMMVALALTL--LRFRILPDDKE 497

  Fly   477 PMKYTINNLLLGSEGGIHLNI---TKVVRD 503
            |.:..  .::|.:|||:.|.:   :.|::|
Mouse   498 PRRKP--EIILRAEGGLWLRVEPLSTVLKD 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	137/493 (28%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	130/472 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900