Protein Alignment Cyp6a19 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 134/546 - (24%)
• Similarity: 232/546 - (42%)
• Gaps: 100/546 - (18%)

  Fly     3 ILLGLVVG--VLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTY--LKF 63
            :||.||||  :|..:..|....|...:|......||     .....|..:   |::..|.  ||.
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPP-----KRNWFWGHL---GLITPTEEGLKN 76

  Fly    64 RKQTDGPFA-GFYLY---AMKYIVITDVDFVKTV-------------LIRDFDKFHDRGVYHNEK 111
            ..|....:: ||.::   .:.:||:...|.::::             .||....:...|:..:
Human    77 STQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLS-- 139

  Fly   112 DDPLTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTD 176
                       .|.||...|:.||..|....:||..:......:.|:.......|..|..|::.:
Human   140 -----------GGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFE 193

  Fly   177 IVSRFTSDVIGICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWLVDLLIFGMPKLAVKLGFQ 239
            .:|..|.|.:..|.|....:....| :|::.  :..|||.|:|...::..:.|          ..
Human   194 HISLMTLDSLQKCIFSFDSHCQERP-SEYIATILELSALVEKRSQHILQHMDF----------LY 247

  Fly   240 FLLPSVQKFY--MKIVQDTID------------------YRMKRKVTRNDFMDTLIDMKQQYDKG 284
            :|....::|:  .::|.|..|                  ::.|.|....||:|.|:..|.:..|
Human   248 YLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGK- 311

  Fly   285 DKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKLEY 348
                .|:..::.|:|..|...|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|...::|:
Human   312 ----ALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372

  Fly   349 DSMQDLFYMEKVINESLRKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTLGIHHDPE 409
            |.:..|.::...:.||||.||....::|..|:    |.....||     |...|:..:|:||:|.
Human   373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPK-----GITCLIDIIGVHHNPT 432

  Fly   410 FYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRF---ELH 471
            .:|:||.:.|.|||.|..|.|...||:||.||||||||..|...::.:.|||::.:|||   ...
Human   433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE 497

  Fly   472 PKTPVPMKYTINNLLLGSEGGIHLNI 497
            |:..:       .|::.:|||:.|.:
Human   498 PRRKL-------ELIMRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	115/473 (24%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	118/481 (25%)