Protein Alignment Cyp6a19 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 157/518 - (30%)
• Similarity: 255/518 - (49%)
• Gaps: 64/518 - (12%)

  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLK----FRKQT 67
            ||...|.|:..:...::..:|:.|||...|             :|..|.: ..||:    |.::.
Human    14 LVATSLVLLYIYGTHSHKLFKKLGIPGPTP-------------LPFLGTI-LFYLRGLWNFDREC 64

  Fly    68 D---GPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKD-DP---LTNNLATIEGQ 125
            :   |...|.|......:||.|.|.:||||:::.     ..|:.|:.. .|   |.:.|:..|.:
Human    65 NEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKEC-----YSVFTNQMPLGPMGFLKSALSFAEDE 124

  Fly   126 KWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICA 190
            :||.:|..|:..|||.|.|.|...:...||.::|.:.:: :.:|:::.:.|....:|.|||....
Human   125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE-AENSKSINLKDFFGAYTMDVITGTL 188

  Fly   191 FGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP------------ 243
            ||:..:||.:|:..|::.....|:          |.|..|.|.:...|.||.|
Human   189 FGVNLDSLNNPQDPFLKNMKKLLK----------LDFLDPFLLLISLFPFLTPVFEALNIGLFPK 243

  Fly   244 SVQKFYMKIVQDTIDYRMKRKVT-RNDFMDTLIDMKQQYDKGDKEN-GLAFNEVAAQAFVFFLAG 306
            .|..|....::...:.|:|.|.. |.||...:||  .|..|..|.: .|:..|:.||:.:...|.
Human   244 DVTHFLKNSIERMKESRLKDKQKHRVDFFQQMID--SQNSKETKSHKALSDLELVAQSIIIIFAA 306

  Fly   307 FEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVV 371
            ::..|||:.|.:||||.:.|||.||:.|||:||.. ...:.||::..:.|::.|:||:||..|||
Human   307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN-KAPVTYDALVQMEYLDMVVNETLRLFPVV 370

  Fly   372 AHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPE-RFDEEQVKKRPTCAF 435
            :.:.|:..|..:.:.  .||..|..|:|....:||||:::.|||||.|| ||.::.........:
Human   371 SRVTRVCKKDIEING--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRY 433

  Fly   436 LPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNL-LLGSEGGIHLNI 497
            :|||||||||||:||....:.:.:...:.||.|:...:|.:|:|  ::|| :|..|..|.|.:
Human   434 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLK--LDNLPILQPEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	141/449 (31%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	142/448 (32%)