DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	521	Identity:	142/521 - (27%)
Similarity:	242/521 - (46%)	Gaps:	51/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGLVVGVLTLVAWWVLQNYTYW----KRRGIPHDP-PNIPLGNTGELWRT---MPLAGILKRTY 60
            ||.|:||...|:|..:...||::    :.:..|..| .|...|:.|.:..|   |.....|..||
Human    20 LLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTY 84

  Fly    61 LKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQ 125
            .:..|...||       ....:::...|.::.:............:::......|.:.|....|.
Human    85 PQGFKLWLGP-------TFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGD 142

  Fly   126 KWKNLRQKLTHTFTSAKMK---SMFSTVLNV-GDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVI 186
            ||...|:.||..|....:|   .:|:..:|: .|:..|:..|    .|..|::.:.:|..|.|.:
Human   143 KWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASE----GSARLDMFEHISLMTLDSL 203

  Fly   187 GICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWLV---DLLIFGMP-----KLAVKLGFQFL 241
            ..|.|..:.|....| :|::.  :..||..|:|:..::   |.|.:..|     :.|..|...|.
Human   204 QKCVFSFESNCQEKP-SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFT 267

  Fly   242 LPSVQKFYMKIVQDTIDYRMKRKVTRN--DFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFL 304
            ...:|:....:....||..:|.|....  ||:|.|:..|   |:..||  |:..::.|:|..|..
Human   268 DAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSK---DEDGKE--LSDEDIRAEADTFMF 327

  Fly   305 AGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKLEYDSMQDLFYMEKVINESLRKH 368
            .|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|...::|:|.:..|.::...|.||||.|
Human   328 EGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   369 PVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTC 433
            |.|..::|..|:.:...:.: .|..|...|::.:|||::|..:|:||.:.|.|||:|.:|:|...
Human   393 PPVPVISRCCTQDFVLPDGR-VIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPL 456

  Fly   434 AFLPFGAGPRNCIGLRF--GRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIHLN 496
            ||:||.||||||||..|  ..|:|::.|.||    .|.:.|....|.:..  .|:|.:|||:.|.
Human   457 AFIPFSAGPRNCIGQAFAMAEMKVVLALTLL----HFRILPTHTEPRRKP--ELILRAEGGLWLR 515

  Fly   497 I 497
            :
Human   516 V 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	132/485 (27%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	128/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810