Protein Alignment Cyp6a19 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 109/528 - (20%)
• Similarity: 208/528 - (39%)
• Gaps: 96/528 - (18%)

  Fly     1 MAILLGLVVGVLTLVA-----WWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAG-----I 55
            :|.|...:|.|..|:|     |.:....|..|...:|     ||.|:.|     .||.|     :
Human    12 LATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLP-----IPKGSMG-----FPLIGETGHWL 66

  Fly    56 LKRT-YLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDD-PLT-- 116
            |:.: :...|::..|.....:|.....|.:|..:.|:.:|:         |.:|....: |.:
Human    67 LQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILM---------GEHHLVSTEWPRSTR 122

  Fly   117 -----NNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTD 176
                 |.::...|...:|.|:..:..|:...::|....:..|..:.:|.    .||..:.:.|..
Human   123 MLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRA----WSSHPEAINVYQ 183

  Fly   177 IVSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLL------IFGMPKLAVK 235
            ...:.|..:           ::|      |.:|:| :.|...|.|.::.      :|.:|   |.
Human   184 EAQKLTFRM-----------AIR------VLLGFS-IPEEDLGHLFEVYQQFVDNVFSLP---VD 227

  Fly   236 LGFQFLLPSVQKFYMKIVQDTIDYRMKRKV--TRN----DFMDTLIDMKQQYDKGDKENGLAFNE 294
            |.|......:|.  .:|:|..::..::.|:  |:.    |.:|.||:..:::.|     .:...|
Human   228 LPFSGYRRGIQA--RQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGK-----EMTMQE 285

  Fly   295 VAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEI--DSVLER----YNGKLEYDSMQD 353
            :.........|.:...::.....:.:|..:..|.:|||.|:  ..:|..    ..|.|..|::..
Human   286 LKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSG 350

  Fly   354 LFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFI 418
            |.|::.||.|.:|....::...|...:.::...  :.|..|..|:.|....|.....:.:...|.
Human   351 LRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG--FQIPKGWSVMYSIRDTHDTAPVFKDVNVFD 413

  Fly   419 PERFDEEQVK-KRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKT-P----VP 477
            |:||.:.:.: |.....:||||.|.|.|:|....::.:.:....|....||||..:| |    ||
Human   414 PDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVP 478

  Fly   478 MKYTINNL 485
            :.:.::.|
Human   479 VLHPVDGL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	90/451 (20%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	93/470 (20%)