DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	496	Identity:	150/496 - (30%)
Similarity:	255/496 - (51%)	Gaps:	56/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVGVLTLVAWWVLQNYTY--WKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTY---LKFRK-- 65
            |:.|.:||.:::...|::  :|:.|||...|             :||.|.:...|   .||.:
Mouse    13 VLLVTSLVLFYIYGTYSHGLFKKLGIPGPKP-------------LPLLGTIFNYYDGMWKFDEDC 64

  Fly    66 -QTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKDDP---LTNNLATIEGQ 125
             :..|...|||......:.|.|.:.:|.||::: :..|.:|..:     .|   :...:...|.:
Mouse    65 YKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF-----GPVGFMKKAITISEDE 124

  Fly   126 KWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVV---DEKISSSSQTLEVTDIVSRFTSDVIG 187
            :||.||..|:.||||.|:|.||..:...||.::|.:   :||    .:.:.:.||...::.|||.
Mouse   125 EWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEK----GEPISMKDIFGAYSMDVIT 185

  Fly   188 ICAFGLKCNSLRDPKAEFVQMGYSALRERRHG-WLVDLLIFG-MPKLAVKLGFQFLLPSVQKFYM 250
            ..:||:..:||.:|:..|||.....|:.:... :|:.:::|. :..:...|.|.........|:.
Mouse   186 GTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFK 250

  Fly   251 KIVQDTIDYRMKR------KVTRNDFMDTLIDMKQQYDKG-DKENGLAFNEVAAQAFVFFLAGFE 308
            |.|:     |||:      :..|.||:..:  |..|..|| :.:..|:..|:||||.:|...|::
Mouse   251 KFVK-----RMKKERLASNQKNRVDFLQLM--MNTQNSKGQESQKALSDLEMAAQAVIFIFGGYD 308

  Fly   309 AGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAH 373
            |.||::...:||||.:.|||.||:.|||..|.. ...:.||::.|:.|::.|:|||||.:|:...
Mouse   309 ATSTSISLIMYELATHPDVQKKLQDEIDRTLPN-KAPVTYDALMDMEYLDMVVNESLRLYPIAIR 372

  Fly   374 LARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPF 438
            |.|::.|..:.:.  .||..||.|::....:|.:||::|||::|.||||.:|.........::||
Mouse   373 LERVSKKDVEING--VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPF 435

  Fly   439 GAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMK 479
            |.|||||||:||..:.:.:.:..::.||..:...:|.:|:|
Mouse   436 GNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	142/470 (30%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	142/470 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720