DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	558	Identity:	142/558 - (25%)
Similarity:	225/558 - (40%)	Gaps:	122/558 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VGVLT--------------LVAWWVLQNYTY-WKR-RGIPHDPPNIPLGNTGELWRTMPLAGILK 57
            |||.|              .:.:.:|::|.: ||. :.||      .:||      |.|..|
Zfish     5 VGVYTYGFVAASVCVICFAYITYQLLKSYLHKWKELKPIP------GIGN------TFPFIG--- 54

  Fly    58 RTYLKFRKQTD--------------GPFAGFYLYAMKYIVITDVDFVKTVLIR--DFDKFHDRGV 106
             ..|:|:...|              .|....::..:.::::...:.|:|||..  ..||.:....
Zfish    55 -NALQFKSNGDFFLQLVGYTTEFQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQF 118

  Fly   107 YHNEKDDP-LTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISS--- 167
            .|     | |...|.|..|.||:..|:.||.||..    |:.:..|.|.:|...|:.||:..
Zfish   119 LH-----PWLGTGLLTSTGDKWRRRRKMLTPTFHF----SILTEFLEVMNEQAEVLIEKLEKQAG 174

  Fly   168 -------SSQTLEVTDIVSRFTSDVIGIC--AFGLKCNSLRDPKAEFVQMGYS----ALRERRHG 219
                   |..||...||          ||  |.|.:..:..:..:|:|:..|.    ..|.:|..
Zfish   175 KGPFNCFSHITLCALDI----------ICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMP 229

  Fly   220 WLVDLLIFGM--------PKLAVKLGFQFLLPSVQKFYMKIVQ-DTIDYRMKRKVTRNDFMDTLI 275
            |.....::..        ..|.:...|...:.:.:..|:..|: |:...:..||  |..|:|.|:
Zfish   230 WYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAEYLSYVESDSESDQGMRK--RRAFLDMLL 292

  Fly   276 DMKQQYDKGDKENG--LAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSV 338
            ..|.       |:|  |...::..:...|...|.:..:..|.:.::.|..:.:||.|.:.|:..|
Zfish   293 KTKD-------EDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEV 350

  Fly   339 LERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLG 403
            .......:..:.::.|.|:|.||.||||..|.|...||......|.:..|  :..||.::|.|..
Zfish   351 FGESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFK--VPKGTNIVVITYA 413

  Fly   404 IHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNF-- 466
            :|.||.|:|:||:|.||||..|....|...|::||.||.|||||.||..|:..:.||.::..|
Zfish   414 LHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNI 478

  Fly   467 -----RFELHPKTPVPMKYTINNLLLGSEGGIHLNITK 499
                 |.||.|         :..|:|..|.||.:.:.:
Zfish   479 VACQKREELRP---------LGELVLRPEQGIWITLER 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	133/513 (26%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	131/511 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810