DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	507	Identity:	142/507 - (28%)
Similarity:	243/507 - (47%)	Gaps:	52/507 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLKFRK 65
            :::...|||.|:||:..:.:..:.::.:.|||...|          |   |..|    |.|.:.|
Zfish     7 LSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRP----------W---PFVG----TLLSYAK 54

  Fly    66 ----------QTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDRGVYHNEKDDPLTNNL 119
                      :..|...|.|...:..:::.|::.:|.||::: :..|.:|.........|.::.:
Zfish    55 GLCNFDMECAKKYGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGI 119

  Fly   120 ATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSD 184
            ..::.::||.:|..|:..|||.::|.:|...:...|..|:.:.:|  ...|.:::.::|:.::.|
Zfish   120 IMVKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKK--DPEQPVKIKEVVAPYSLD 182

  Fly   185 VIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAV---KLGFQFLLPSVQ 246
            ||...:|.:..:|:.:|:..||......::......|: |||...|.||:   |:|......|..
Zfish   183 VITSSSFSVDIDSINNPEDPFVINVKKFIQFNMFNPLL-LLILLFPSLAIPLKKMGVTLFSKSAM 246

  Fly   247 KFYMKIVQDTIDYRMKRKVTRNDFMDTLI------DMKQQYDKGDK-ENGLAFNEVAAQAFVFFL 304
            .|:..:::...|...|....|.||:..::      |..|..|..:: ..||..:|:.:|:.||.|
Zfish   247 DFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFIL 311

  Fly   305 AGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLE----YDSMQDLFYMEKVINESL 365
            .|:|..|||:.|.||.||.|.|..:||..|||.     |..|:    ||::..:.|:|..||||:
Zfish   312 GGYETTSTTLTFLLYNLATNPDCLEKLVEEIDK-----NFPLDTPITYDALMRMDYLEMAINESM 371

  Fly   366 RKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKR 430
            |..|....|.|.|.|....:.  ..|..||.|.:.|..:.|||:.:..|.:|.||||..|...:.
Zfish   372 RLLPTAPRLERSAKKTVVING--LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEF 434

  Fly   431 PTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTI 482
            ...||:|||.|||||||:|:..|.:.:.:..|:.||..|...:|.:|::..:
Zfish   435 LQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	134/476 (28%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	134/473 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720