DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	156/533 - (29%)
Similarity:	261/533 - (48%)	Gaps:	74/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVGVLTLVAWWVL------------QNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTY 60
            :|..|:|..|.:|            :.:..:|::|||...|...||.....:|     |:.|...
  Rat     3 LVSALSLETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR-----GLWKFDM 62

  Fly    61 LKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDR------GVYHNEKDDPLTNN 118
            ..::|  .|...|.:........|.|.:.:|:||::: |..|.:|      |:        ::.:
  Rat    63 ECYKK--CGKIWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPVGI--------MSKS 117

  Fly   119 LATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTS 183
            ::..:.::||..|..|:.||||.::|.||..:.:.||.:::.:.:|: ...:.|.:.::...::.
  Rat   118 ISVAKDEEWKRYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKV-EKGKPLAMKEVFGAYSM 181

  Fly   184 DVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLP----- 243
            |||...:|.:..||:.:||..||:   ...:.:|..:...|.      |:|.| |.||.|
  Rat   182 DVITSTSFEVNINSINNPKDPFVE---KVKKFQRFDFFDPLF------LSVVL-FPFLTPIYEML 236

  Fly   244 --------SV---QKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFN--EV 295
                    ||   |||..::.|..:|.:.|.:|   ||:..:  |....:..||.:..|.:  |:
  Rat   237 NICLFPKDSVAFFQKFVYRMKQTRLDSKHKHRV---DFLQLM--MNAHNNSKDKVSHKALSDIEI 296

  Fly   296 AAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKV 360
            .|||.:|..|.:|..|:|:.|.||.||.:.|.|.||:.|||..|.. .....||::.::.|::.|
  Rat   297 VAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPN-KAPPTYDTVMEMEYLDMV 360

  Fly   361 INESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEE 425
            :||:.|.:|:...|.|:..|..:...  .||..|:.|::....:.|||:.:||||:|:||||.:|
  Rat   361 LNETPRLYPIGYRLERVCKKDIKLDG--VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKE 423

  Fly   426 QVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSE 490
            .........:||||.|||||||:||..|.:.:.|..::.||.|:|..:|.:|:|.: ...|.|.|
  Rat   424 NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLS-RQRLFGPE 487

  Fly   491 GGIHLNITKVVRD 503
            ..|.|.:  |.||
  Rat   488 KPIVLKV--VPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	144/487 (30%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	137/455 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010