DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	521	Identity:	138/521 - (26%)
Similarity:	247/521 - (47%)	Gaps:	84/521 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLKFRK 65
            :::...||..|:||:..:.:..:.::|:.|||...|          |   |..|    |:|.:.|
Zfish     7 LSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRP----------W---PFFG----TFLSYTK 54

  Fly    66 QTDGPFAGFYLY----AMKY-------------IVITDVDFVKTVLIRD-FDKFHDRGVYHNEKD 112
                   ||:.:    |.||             :::||::.:||::::: :..|.:|...:.:..
Zfish    55 -------GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLA 112

  Fly   113 DPLTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDI 177
            .||.:.::.::.::||.:|..|:..|||.::|.:|...:...|..|:.:.::  ...|.:::.::
Zfish   113 GPLADGISAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKR--DHEQPVKIKEV 175

  Fly   178 VSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIF-----GMPKLAVKLG 237
            |:.::.||:...:|.:..:|:.:|...||....:.|   :......|::|     .:..|..|:|
Zfish   176 VAPYSLDVVTSSSFSVDIDSINNPDDPFVTNIKNFL---KFSLFSPLILFLTLFPSIANLLGKMG 237

  Fly   238 FQFLLPSVQKFYMKIVQDTIDYRMKRKVT--------RNDFMDTLI------DMKQQYDKGDKEN 288
            ......|:..|:         |...||:.        |.||:..:|      |..:.........
Zfish   238 ISVFSRSIMNFF---------YTALRKIKDEHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVK 293

  Fly   289 GLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQD 353
            ||..:|:.:|:|:|.|.|:|..|||:.|.|:.||.|.|..:||..|||.... .:..:.||::..
Zfish   294 GLTDHEILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFP-LDTPISYDALMK 357

  Fly   354 LFYMEKVINESLRKHPVVAHLARIATKPYQHSN---PKYFIEAGTGVLVSTLGIHHDPEFYPEPE 415
            :.|:|..||||:|..|....|.|:..|..:.:.   ||     .|.|.:.|..::.||:.:..|:
Zfish   358 MDYLEMSINESMRLLPTAPRLERVCKKTVELNGITIPK-----DTLVAIPTYVLNRDPQLWDSPQ 417

  Fly   416 KFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKY 480
            :|.||||..|...:....||:|||.|||||||:||..|.|.:.:..|:.||..|...:|.:|::.
Zfish   418 EFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLEL 482

  Fly   481 T 481
            |
Zfish   483 T 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	130/490 (27%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	130/490 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.720