DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	166/521 - (31%)
Similarity:	294/521 - (56%)	Gaps:	30/521 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDP-PNIPLGNTGELWRTMPLAGI-LKRTYLKF 63
            |..|:.|.|.:|||..:::.::|.||:|||.|.:. ..||.|....:||.....|: :...|:|.
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKS 65

  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWK 128
            :::.    .|.||.....::|.|.|..:.||.:||..|||||||.:|:.|||:.|:.::.||.|:
  Fly    66 KERV----LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWR 126

  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSS-QTLEVTDIVSRFTSDVIGICAFG 192
            ::|..|:..|||.|:||||||..::||:|:..:.:::.... :.:::..::..:..|:|....||
  Fly   127 SMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFG 191

  Fly   193 LKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLA---VKLGFQFLLPSVQKFYMKIVQ 254
            |..||..:|..:|.::...|....|...:..::||.:|.:|   .::||:   ..|....::||:
  Fly   192 LDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFK---NPVGLAMLQIVK 253

  Fly   255 DTIDYRMKRKVTRNDFMDTLIDMKQ--QYDKGDKEN------------GLAFNEVAAQAFVFFLA 305
            :|::||.|..:.|.|.:..||.::.  :.|:.|:::            .::...:.||||:|::|
  Fly   254 ETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIA 318

  Fly   306 GFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPV 370
            |.|...:|..||:||||...::..:|:.|:|..|.:.:||:.|||:..:.:::..:.|::||:|.
  Fly   319 GQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYPG 383

  Fly   371 VAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAF 435
            :..|.|..|:.|...:..:.|..||.|::|..|||||.|::|:||.:.||||.||.....|| ||
  Fly   384 LPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPT-AF 447

  Fly   436 LPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIHLNITKV 500
            :|||.|||.||..|.||:...:.:..::.||..|:..::.:  ::..:.:.|..:.|:.:.::|.
  Fly   448 MPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIALIPKHGVRVRLSKR 510

  Fly   501 V 501
            |
  Fly   511 V 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	151/482 (31%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	143/451 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461190
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900