DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	146/512 - (28%)
Similarity:	252/512 - (49%)	Gaps:	46/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLKF-------RKQTDGPFAGFY 75
            |...|..::|.|||.::.|.:..||         :||:..|....|       .|.....|.|.:
  Fly    19 WASANNDFFKDRGIAYEKPVLYFGN---------MAGMFLRKRAMFDIVCDLYTKGGSKKFFGIF 74

  Fly    76 LYAMKYIVITDVDFVKTVLIRDFDKF-HDRGVYHNEKDD---PLTN----NLATIEGQKWKNLRQ 132
            ......:::.|.|.:|.:.|:|||.| :.|.|:....||   .::|    :|.::...:||::|.
  Fly    75 EQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARWKDMRS 139

  Fly   133 KLTHTFTSAKMKSMFSTVLNVGDEMIRVV---DEKISSSSQTLEVTDIVSRFTSDVIGICAFGLK 194
            .|:..||.:||:.||..:..|..|.:..:   |.::..:.  |::.|..:|||:|||...||||:
  Fly   140 TLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE--LDMKDYCTRFTNDVIASTAFGLQ 202

  Fly   195 CNSLRDPKAEFVQMG-----YSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQKFYMKIVQ 254
            .||.:|.:..|.|||     ::.|:..:.     :|.|.:..|...|..:.......::::::|.
  Fly   203 VNSFKDRENTFYQMGKKLTTFTFLQSMKF-----MLFFALKGLNKILKVELFDRKSTQYFVRLVL 262

  Fly   255 DTIDYRMKRKVTRNDFMDTLID----MKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMG 315
            |.:.||.:..:.|.|.::.|::    ::.:..|.......:..::.||.||||.||||..:..|.
  Fly   263 DAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFETSAVLMC 327

  Fly   316 FTLYELACNQDVQDKLRAEIDSVLERYNGK-LEYDSMQDLFYMEKVINESLRKHPVVAHLARIAT 379
            ||.:||..|||||.:|..|:..|.:...|| |.|:::..:.|:::|:||.|||.|....:.|...
  Fly   328 FTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECN 392

  Fly   380 K--PYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGP 442
            |  .:.....|..::.|..:.:.|.|.|.||:::..|.||.||||.:|..:......:.|||.|.
  Fly   393 KDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFGLGQ 457

  Fly   443 RNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIHLNITK 499
            |||||.||..::....:..|:.::||....|:.:|::...:...|..:||..:.:.:
  Fly   458 RNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKLVQ 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	140/492 (28%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	140/489 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461238
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800