Protein Alignment Cyp6a19 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 149/528 - (28%)
• Similarity: 247/528 - (46%)
• Gaps: 65/528 - (12%)

  Fly     4 LLGLVVGVLTLVAWWVLQNYTYW----KRRGIPHDPP-NIPLGNTGELWRTMPLAGILKRTYLKF 63
            ||.|:||...|:|..:...||::    :.|..|..|. |..||:.|.:..:.  .|:|   |.:.
Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSE--EGLL---YTQS 79

  Fly    64 RKQTDGPFAGFYLYAMKYIV-ITDVDFVKTVL-----IRDFDKFHDRGVYHNEKDDPLTNNLATI 122
            ...|.|....:::.....|| |....::|.||     |...||     |:::.....|.:.|...
Human    80 LACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDK-----VFYSFLKPWLGDGLLLS 139

  Fly   123 EGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEK----ISSSSQTLEVTDIVSRFTS 183
            .|:||...|:.||..|..    ::....:.:.:|.:.::..|    .|..|..|::.:.:|..|.
Human   140 AGEKWSRHRRMLTPAFHF----NILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTL 200

  Fly   184 DVIGICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWL---VDLLIFGMP-----KLAVKLGF 238
            |.:..|.|....:....| :|::.  :..|||..:||..:   :|.|.:..|     :.|.:|..
Human   201 DSLQKCVFSFDSHCQEKP-SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVH 264

  Fly   239 QFLLPSVQKFYMKIVQDTID--YRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFV 301
            .|....:|:....:....:|  .:.|.|....||:|.|:..|   |:..|:  |:..::.|:|..
Human   265 DFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSK---DEDGKK--LSDEDIRAEADT 324

  Fly   302 FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKLEYDSMQDLFYMEKVINESL 365
            |...|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|...::|:|.:..|.::...|.|||
Human   325 FMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389

  Fly   366 RKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQ 426
            |.||.|..::|..|:    |.....||     |...|:|..|.||:|..:|:||.:.|.|||.:.
Human   390 RLHPPVPAVSRCCTQDIVLPDGRVIPK-----GIICLISVFGTHHNPAVWPDPEVYDPFRFDPKN 449

  Fly   427 VKKRPTCAFLPFGAGPRNCIGLRF--GRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGS 489
            :|:|...||:||.||||||||..|  ..|:|::||.||    ||.:.|....|.:..  .|:|.:
Human   450 IKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL----RFRVLPDHTEPRRKP--ELVLRA 508

  Fly   490 EGGIHLNI 497
            |||:.|.:
Human   509 EGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	129/455 (28%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	131/469 (28%)