DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp6g1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	175/521 - (33%)
Similarity:	274/521 - (52%)	Gaps:	43/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRT-----MPLAGILKRTYLKF 63
            :|.:||..|..:..|..:|::||:|:|||:.||...:|||..:::.     |.|:.|.....||
  Fly     6 VLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK- 69

  Fly    64 RKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPL-TNNLATIEGQKW 127
                |....|.|......::|.|::.:|::||:||::||:|....:...||| .|||..:....|
  Fly    70 ----DEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHW 130

  Fly   128 KNLRQKLTHTFTSAKMKSMFSTVLNVGDEM---IRVVDEKISSSSQTLEVTDIVSRFTSDVIGIC 189
            |.:|.|||..|||.|:|.|::.:..:|.::   ::...||.|.|..| |:.:|.::|::|.|...
  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFIT-EIKEICAQFSTDSIATI 194

  Fly   190 AFGLKCNSLRDPKAEFVQMG-----YSALRERRHGWLVDLLI-FGMPKLAVKLGFQFLLPSVQKF 248
            |||::.|||.:|.|||...|     ::..|.:      |..: |.:|||...:..||.......|
  Fly   195 AFGIRANSLENPNAEFRNYGRKMFTFTVARAK------DFFVAFFLPKLVSLMRIQFFTADFSHF 253

  Fly   249 YMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNE--VAAQAFVFFLAGFEAGS 311
            ....:...::.|.:..:.|||.:|.|:.::::......:...|.|:  :.|||.|||.||||..|
  Fly   254 MRSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSS 318

  Fly   312 TTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLAR 376
            :||.|.|||:|.:.::|.:||.||:..|....|.|.|:.:|.|.|:..|::|.||.:||:..|.|
  Fly   319 STMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDR 383

  Fly   377 ----------IATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRP 431
                      ::.||:.    .|.:|.||.|.:....:||||:::..|.:|.||||.....|...
  Fly   384 EYESVEGQPDLSLKPFY----DYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIV 444

  Fly   432 TCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIHLN 496
            ..|:.|||:||.||||.|.|.:|..:||..|:.|........|...||:.....:|.::|||||.
  Fly   445 AMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLE 509

  Fly   497 I 497
            |
  Fly   510 I 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	161/489 (33%)
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	155/467 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461094
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800