Protein Alignment Cyp6a19 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 495
• Identity: 118/495 - (23%)
• Similarity: 225/495 - (45%)
• Gaps: 65/495 - (13%)

  Fly     7 LVVGVLTLVAWWVLQNYTYWKRRGIPHDP----PNIPLGNTGELWRTMPLAG-ILKRTYLKFRKQ 66
            |::|...|:|:.:...:.:..|....|.|    |:..||:....|:.....| :|:..:|.:.|:
  Rat     6 LLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAKK 70

  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQ------ 125
            . ||.....::....:::|..:.||..|:.  .|::        ||..:...:.|:.|:
  Rat    71 Y-GPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYN--------KDSKMYRAIQTVFGERLFGQG 124

  Fly   126 --------KWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQT-LEVTDIVSRF 181
                    :|...|:.:...|:.:.:.|:..|.....::::.:::.|  :..|| :.:.|:::..
  Rat   125 LVSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAK--ADGQTPVSMQDMLTCA 187

  Fly   182 TSDVIGICAFGLKCNSL---RDPKAEFVQM---GYSALRERRHGWLVDLLIFGMPKLAVKLGFQF 240
            |.|::...|||::.:.|   :.|.::.|::   |.||.|        :.|...||      |.:.
  Rat   188 TIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASR--------NTLAKFMP------GKRK 238

  Fly   241 LLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFV-FFL 304
            .|..:::....:.|...|:..:|:.......|...|:..|..|.  |.|...:||....|| ||:
  Rat   239 QLREIRESIRLLRQVGKDWVQRRREALKRGEDVPADILTQILKA--EEGAQDDEVLLDNFVTFFI 301

  Fly   305 AGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL--ERYNGKLEYDSMQDLFYMEKVINESLRK 367
            ||.|..:..:.||:.||:...::..:|:||:|.|:  :|:   |:|:.:..|.|:.:|:.||||.
  Rat   302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH---LDYEDLGRLQYLSQVLKESLRL 363

  Fly   368 HPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPT 432
            :|......|:..:.......:  :...|.:|.||..:.....::.:|..|.|:||.....|.|.|
  Rat   364 YPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426

  Fly   433 CAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP 472
              :.||..|.|:|||.:|.:|:|.:.:|.|:....|.|.|
  Rat   427 --YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	103/430 (24%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	105/440 (24%)