DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	156/493 - (31%)
Similarity:	246/493 - (49%)	Gaps:	47/493 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVGVLTLVAW-WVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLK-----FRK 65
            ||:..:.|:.: |....:..::.|.:..:.|...|||       |..:.:.|.::.|     :.:
  Fly     8 LVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGN-------MAASALQKASFQKQISEFYNR 65

  Fly    66 QTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATI-EGQKWKN 129
            .......|.:......|.|.|...:|.:.::|||.|.:.... |..::.|.|::..: ..|.|:|
  Fly    66 TRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTL-NIPNERLVNDMLNVMRDQHWRN 129

  Fly   130 LRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQ--------TLEVTDIVSRFTSDVI 186
            :|..||..||||||::|| |::|   |......|.:.||..        .|::..:.::.::|||
  Fly   130 MRSVLTPVFTSAKMRNMF-TLMN---ESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVI 190

  Fly   187 GICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSV-----Q 246
            ...|||||.||..||:.||..:|.:....|.    :..|.|.|..||.|: |.|...::     .
  Fly   191 ATTAFGLKVNSFDDPENEFHTIGKTLAFSRG----LPFLKFMMCLLAPKV-FNFFKLTIFDSTNV 250

  Fly   247 KFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGS 311
            ::::::|.|.:.||.|..:||.|.:..|::.|    |..|:| ...:|:.||.|:||.|.||..|
  Fly   251 EYFVRLVVDAMQYREKHNITRPDMIQLLMEAK----KESKDN-WTDDEIVAQCFIFFFAAFENNS 310

  Fly   312 TTMGFTLYELACNQDVQDKLRAEIDSVLERYNG-KLEYDSMQDLFYMEKVINESLRKHPVVAHLA 375
            ..:..|.|||..|.|:|::|..|:....|...| .|.||:.|::.||:.||:|||||..:.|...
  Fly   311 NLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAAD 375

  Fly   376 RIATKPY---QHSNPKYF-IEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFL 436
            |:..|.|   .....|.| .:||..:.:...|:|.|..|:|:|::|.||||.|.:.|......:|
  Fly   376 RLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYL 440

  Fly   437 PFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKT 474
            |||.|||:|||.|:..||....|..|:.|::.|..|:|
  Fly   441 PFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	151/467 (32%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	150/462 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461274
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800