DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	141/517 - (27%)
Similarity:	250/517 - (48%)	Gaps:	39/517 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGI--LKRTYLKFRKQ 66
            |:.||||:|..|..|   ||.||::||:|...|.:..||...:: ||....|  |...|.:::.:
  Fly     8 LVSLVVGLLYAVLVW---NYDYWRKRGVPGPKPKLLCGNYPNMF-TMKRHAIYDLDDIYRQYKNK 68

  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHN--EKDDPL-TNNLATIEGQKWK 128
            .|.  .|.:......:::.:....:.|.:.:|..|||..:..|  ||.|.: .||..::.|:|||
  Fly    69 YDA--VGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLTGEKWK 131

  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKIS-SSSQTLEVTDIVSRFTSDVIGICAFG 192
            ..|..:|...|..::|:::.....|..::...|::::. .|...::...:...||::::..|..|
  Fly   132 TRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCFTTEMVTDCVLG 196

  Fly   193 LKCNSLRDPKAEFVQMGYSALRER-RHGW---LVDLLIFGMPKLAVKLGFQFLLPSVQKFYMKIV 253
            |...|..|.....:    |.:.:. ...|   |..:|....|.|:..:..:|:...|::|::.::
  Fly   197 LGAESFSDKPTPIM----SKINDLFNQPWTFVLFFILTSSFPSLSHLIKLRFVPVDVERFFVDLM 257

  Fly   254 QDTIDYRMK-----RKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTT 313
            ...::.|..     ::..|:||:|.::.:      |:|.| |...::.|.:..|.|.|||..:|.
  Fly   258 GSAVETRRAQLAAGKQFERSDFLDYILQL------GEKRN-LDNRQLLAYSMTFLLDGFETTATV 315

  Fly   314 MGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIA 378
            :...|..|..|::.|:.||.||.|.|:  :|.:.::.:.||.|::..:.|::|..|......::.
  Fly   316 LAHILLNLGRNKEAQNLLREEIRSHLQ--DGTIAFEKLSDLPYLDACVQETIRLFPPGFMSNKLC 378

  Fly   379 TKPYQHSN---PKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK--RPTCAFLPF 438
            |:..:..|   |.:.:|.||.|:|.......|.||:|.|:.|.||||.|....|  |....|:.|
  Fly   379 TESIEIPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFRERGVFMGF 443

  Fly   439 GAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGGIHLNITKV 500
            |.|||.|||:||..:|:...:..||..|..:::.||.....|....::.|..|||.|::.|:
  Fly   444 GDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDYEPGQIITGLRGGIWLDLEKL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	125/482 (26%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	125/482 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460974
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900