DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp308a1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	141/537 - (26%)
Similarity:	242/537 - (45%)	Gaps:	87/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLGLVVGVL---TLVAW-WVLQNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGIL------KR 58
            :|.||:.:|   ||:.| |   ...:|:|.|:     ..|.|     |   ||.|.:      :|
  Fly     1 MLPLVLFILLAATLLFWKW---QGNHWRRLGL-----EAPFG-----W---PLVGNMLDFALGRR 49

  Fly    59 TYLKFRKQ--TDGP---FAGFY-LYAMKYIVITDVDFVKTVLI-RDFDKFHDRGVYHNEKDDPL- 115
            :|.:..::  |..|   :.||| |:....|::.|.:.::.:|: |:|....|..||.:.:.|.|
  Fly    50 SYGEIYQEIYTRNPGLKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLA 114

  Fly   116 TNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSR 180
            ::|.....|.:|:.||..|...||.::::.....|...    .:::.:::...  ..|..|:.:|
  Fly   115 SHNPFIANGDRWRVLRADLVPLFTPSRVRQTLPHVARA----CQLLRDQVPLG--RFEAKDLATR 173

  Fly   181 FTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLL------------IFGMPKLA 233
            :|..|:....|||..:.|.      :.|..:....|...||..|.            :...|:|.
  Fly   174 YTLQVVASAIFGLDAHCLG------IHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLG 232

  Fly   234 VKLGFQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQ 298
            ..:|.:::...:|.::.::|:        .:...::.:..|.:.|:         ||...|:|..
  Fly   233 RLIGHRYVPLPLQHWFRELVE--------ARSGGDNLLQWLAESKR---------GLGKEELAGH 280

  Fly   299 AFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKL-EYDSMQDLFYMEKVIN 362
            |....|.|:|..:..:.|.|||||.|:|.|.:|..|:|.|.:|:.|.| :..::.:|.|.|..:.
  Fly   281 ATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALL 345

  Fly   363 ESLRKHPVVAHLARIATK----PYQHS--NPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPER 421
            |:||.||.:..|.:..||    |.|.|  :.:..:..||.:::....||.||..||.|.:|.|||
  Fly   346 EALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPER 410

  Fly   422 FDEEQVKKRPT-CAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNL 485
            |    :.:.|. |.||.||||||.|.|:|.|.:|....|..|:.:...:|..:....::.:....
  Fly   411 F----LNQPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTF 471

  Fly   486 LLGSEGGIHLNITKVVR 502
            |..|..||.|:..:..|
  Fly   472 LTASRNGIWLSFKRRTR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	128/496 (26%)
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	128/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460938
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900