DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a19 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	132/532 - (24%)
Similarity:	241/532 - (45%)	Gaps:	73/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVGVLTL---VAWWVLQNYTYWKRRGIPHDPPNIPLGNT--GELWRTMPLAGILKRTYLKFRKQ 66
            |::|:.||   :..:::.|:.:|:|||:. :|..:||..:  ..:|........::..|:.:|..
  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVT-EPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNT 68

  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRG---VYHNEKDDPLTNNLATIEGQKWK 128
            ..  :.|.||.....:::.:...|..:.:..|..|.:..   :....||..:..|...:||::|:
  Fly    69 HS--YVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWR 131

  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGL 193
            :.|...:...|:.::::..:.:..|..::.:.:..| |:..:.|:..|:..|||.:.:..|..|:
  Fly   132 HQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIK-SAGGKDLDCIDLGLRFTGESLFDCVLGI 195

  Fly   194 KCNSLRDPKAEFVQMGYSALRERR--------HGWLVDLLIFGMPKLAVKLGFQFLLPSVQKFYM 250
            :..:..|.....|:..:....|.|        ||...:|..:..||:..:        |..:||.
  Fly   196 QARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPR--------SHDRFYG 252

  Fly   251 KIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMG 315
            :::.:.:..|..:...||||::.|::|:::.|       |:..::|:.|..|...|.:..|.::.
  Fly   253 QMISEALRLRRSKHQERNDFINHLLEMQRELD-------LSEEDMASHAMTFMFDGLDTTSNSIA 310

  Fly   316 FTLYELACNQDVQDKLRAEIDSVLERYNGKL-EYDSMQDLFYMEKVINESLRKHPVVAHLARIAT 379
            ..|..|..|.|.|.:|..|:.  |....|.| :.|::.||.|:....|||||.:|.....::..|
  Fly   311 HCLLLLGRNPDCQRRLYEELQ--LVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCT 373

  Fly   380 KPYQ-----HSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK-RPTCAFLPF 438
            |.|:     ||.| ..:..|..|:|....:|:||:.||||:.|.||||.:..:|. :....||.|
  Fly   374 KEYELRGSHHSEP-LKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGF 437

  Fly   439 GAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSE-----------GG 492
            |.|||.|:|:|.|.......||.::..|...:.|:|           |.|:|           ||
  Fly   438 GNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRT-----------LNGTELDPLIFVGVHKGG 491

  Fly   493 IHL------NIT 498
            |.|      |:|
  Fly   492 IWLQFVPRKNVT 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	120/493 (24%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	117/483 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460926
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900