DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a19 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	125/460 - (27%)
Similarity:	207/460 - (45%)	Gaps:	66/460 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GPFAGFYLYAMKYIVITDVDFVKTVL-----IRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWK 128
            |||       :..:|:...|::|.||     |...|:|     :::.....|.:.|...:|.||.
  Rat   101 GPF-------LPLLVLVHPDYIKPVLGASAAIAPKDEF-----FYSFLKPWLGDGLLISKGNKWS 153

  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEK-----ISSSSQTLEVTDIVSRFTSDVIGI 188
            ..|:.||..|....:|    ..:.:.::.:.::..|     ...|..:.::.:.||..|.|.:..
  Rat   154 RHRRLLTPAFHFDILK----PYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSLQK 214

  Fly   189 CAFGLKCN---SLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQKFYM 250
            |.|....:   .|.|..:..:::  |||..||...|...|.|.....|....|:....:|..|..
  Rat   215 CVFSYSSDCQEKLSDYISSIIEL--SALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVHNFTT 277

  Fly   251 KIVQDTIDYRMKRKVTRN---------------DFMDTLIDMKQQYDKGDKENGLAFNEVAAQAF 300
            :::|      .:|:..|.               ||:|.|:..|   |:..||  |:..::.|:|.
  Rat   278 EVIQ------QRRRALRELGAEAWLKAKQGKTLDFIDVLLLAK---DEEGKE--LSDEDIRAEAD 331

  Fly   301 VFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLE-RYNGKLEYDSMQDLFYMEKVINES 364
            .|...|.:..|:.:.:.|:.||...:.|||.|.||..|:: |...:|::|.:..|.:....|.||
  Rat   332 TFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKES 396

  Fly   365 LRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKK 429
            ||:.|.|..::|..|:..:..:.: .|..|...|||..|.|::|..:|:.:.:.|.|||.:..::
  Rat   397 LRQFPPVTLISRRCTEDIKLPDGR-IIPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIPQQ 460

  Fly   430 RPTCAFLPFGAGPRNCIGLRF--GRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSEGG 492
            |...||:||.||||||||..|  ..|:|::.|.||  .||..:.....|..|   ..|:|.:|.|
  Rat   461 RSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLL--RFRLSVDRTRKVRRK---PELILRTENG 520

  Fly   493 IHLNI 497
            :.||:
  Rat   521 LWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	123/456 (27%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	123/456 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900