Protein Alignment Cyp6a19 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 124/525 - (23%)
• Similarity: 226/525 - (43%)
• Gaps: 82/525 - (15%)

  Fly     7 LVVGVLTLVAWWVLQNYTYWKR-RGIPHDPPNIPLGNTGELWRTMPLAG---ILKRTYLKFRKQ- 66
            ||:.:|..||.:..:    |:: |.||            .:.|..||.|   ::|....:|.:|
Human    29 LVLSLLQRVASYARK----WQQMRPIP------------TVARAYPLVGHALLMKPDGREFFQQI 77

  Fly    67 ---TDG----PFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEG 124
               |:.    |....::..:..:.:.:.:.|:.:|..  .|..|:...:...:..|...|.|..|
Human    78 IEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTS--SKQIDKSSMYKFLEPWLGLGLLTSTG 140

  Fly   125 QKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISS--SSQTLEVTDIVSRFTSDVIG 187
            .||::.|:.||.||..    ::....|::.:|...::.:|:..  :.:.......::....|:|.
Human   141 NKWRSRRKMLTPTFHF----TILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIIC 201

  Fly   188 ICAFGLKCNSLRDPKAEFV----QMGYSALRERRHGWL-VDL--LIFGMPKLAVKLGFQF--LLP 243
            ..|.|....:..:..:|:|    :|.....|..:..|| :||  |:|       |.|::.  .|.
Human   202 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMF-------KEGWEHKKSLQ 259

  Fly   244 SVQKFYMKIVQDTIDYRMKRKVTRND-------------FMDTLIDMKQQYDKGDKENGLAFNEV 295
            .:..|...::.:..:.....:..|.|             |:|.|:.:..     |:.|.|:..::
Human   260 ILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD-----DEGNRLSHEDI 319

  Fly   296 AAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKV 360
            ..:...|...|.:..:..:.::||.|..|.:||.|:..|:|.|..:.:.....:.::.|.|:|.|
Human   320 REEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECV 384

  Fly   361 INESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEE 425
            |.|:||..|.|...||..::..:.:.  |.:..||..::....:|.||.::|.||:|.||||..|
Human   385 IKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPE 447

  Fly   426 QVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGSE 490
            ..:.|...|::||.||||||||.:|..|:....|:.::.:|..|.:.|...          ||.|
Human   448 NAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREE----------LGLE 502

  Fly   491 GGIHL 495
            |.:.|
Human   503 GQLIL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	107/454 (24%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	109/462 (24%)