Protein Alignment Cyp6a19 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 137/532 - (25%)
• Similarity: 228/532 - (42%)
• Gaps: 70/532 - (13%)

  Fly     5 LGLVVGVLTLVAWWVL--------QNYTY--WKRRGI---PHDPPNIPLGNTGELWRTMPLAGIL 56
            ||.|.|:|.:.:..:|        |.|.:  |..:.:   |..|.:...|:..|......|..|.
Human    12 LGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQ 76

  Fly    57 KRTYLKFRKQTDGPFAGFYLYAMKY-IVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLA 120
            :|.      :|......::::..|. :.:.|.|::|.:|.|...|.|....:...:   :...|.
Human    77 ERV------KTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR---IGYGLL 132

  Fly   121 TIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVD--EKISSSSQTLEVTDIVSRFTS 183
            .:.||.|...|:.||..|.:..:|.....   :.|.:..::|  |::......|||...||..|.
Human   133 LLNGQTWFQHRRMLTPAFHNDILKPYVGL---MADSVRVMLDKWEELLGQDSPLEVFQHVSLMTL 194

  Fly   184 DVIGICAFGLKCNSLRDPKAEFVQMGYSALRE-----RRHGWLVDLLIFGMPKL------AVKLG 237
            |.|...||..:.:...|..::......|.|..     .|:.:..:..|:.:...      |.:|.
Human   195 DTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLA 259

  Fly   238 FQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENG--LAFNEVAAQAF 300
            .|.....:|....::.::....::||| ...||:|.|:..|.       |||  |:..::.|:..
Human   260 HQHTDQVIQLRKAQLQKEGELEKIKRK-RHLDFLDILLLAKM-------ENGSILSDKDLRAEVD 316

  Fly   301 VFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESL 365
            .|...|.:..::.:.:.||.||.:...|::.|.||..:|.. ...:.::.:..:.|....|.|:|
Human   317 TFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASITWNHLDQMPYTTMCIKEAL 380

  Fly   366 RKHPVVAHLAR----IATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQ 426
            |.:|.|..:.|    ..|.|...|.||     |..||:|..|:||:|:.:|..|.|.|.||....
Human   381 RLYPPVPGIGRELSTPVTFPDGRSLPK-----GIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGS 440

  Fly   427 VKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHP---KTPVPMKYTINNLLLG 488
            .:.  :.|||||..|.|||||.:|...|:.:..||.:  .||||.|   :.|:||.    .|:|.
Human   441 AQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTL--LRFELLPDPTRIPIPMA----RLVLK 497

  Fly   489 SEGGIHLNITKV 500
            |:.||||.:.::
Human   498 SKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	126/485 (26%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	127/486 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900